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April 2006

Frontotemporal Lobar Degeneration With Motor Neuron DiseaseA Clinical and Pathological Spectrum

Arch Neurol. 2006;63(4):489-490. doi:10.1001/archneur.63.4.489

Frontotemporal lobar degeneration (FTLD) is second only to Alzheimer disease as a cause of progressive cognitive impairment. The diagnostic category encompasses a phenotypic and pathologically heterogeneous group of disorders that begs to be split into distinct, clinically recognizable units. The clinical phenotype involves a variable spectrum of impairments in behavior and language, psychiatric symptoms, and motor signs in pyramidal and extrapyramidal systems.13

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