We describe a primary cerebral amyloidoma that mimicked high-grade glioma on neuroimaging. Histologic analysis confirmed amyloidoma. Because neuroimaging characteristics of intracerebral amyloidoma can be confused for high-grade glioma, these lesions must be confirmed histologically before initiating aggressive treatment for presumptive high-grade glioma.
Amyloidosis is a diverse group of acquired or hereditary diseases characterized by extracellular tissue deposits of insoluble proteins in 1 or several organs. The defining feature of amyloidomas is the localized tumorlike deposition of amyloid.
Ragel BT, Blumenthal DT, Browd SR, Salzman KL, Jensen RL. Intracerebral Amyloidoma Can Mimic High-Grade Glioma on Magnetic Resonance Imaging and Spectroscopy. Arch Neurol. 2006;63(6):906-907. doi:10.1001/archneur.63.6.906