In the March 2006 issue of the ARCHIVES, Josephs et al1 reported on 16 patients with Parkinson disease (PD) suffering from disabling tremor but otherwise mild parkinsonian signs. The clinical course of these patients revealed mild progression other than tremor and a disappointing response to levodopa therapy. The family histories in the cases were remarkable with 10 of 16 patients reporting tremor or PD in at least 1 immediate family member. The authors suggested the term benign tremulous parkinsonism to be applied to this clinical constellation.
Haugarvoll K, Uitti RJ, Farrer MJ, Wszolek ZK. LRRK2 Gene and Tremor-Dominant Parkinsonism. Arch Neurol. 2006;63(9):1346-1347. doi:10.1001/archneur.63.9.1346-b