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Citations 0
Correspondence
December 2006

Data vs Conclusions in the Optic Neuritis Vaccination Investigation—Reply

Arch Neurol. 2006;63(12):1810. doi:10.1001/archneur.63.12.1810

In reply

Use of the DMSS database has allowed the largest vaccine safety investigation of optic neuritis ever published; the power to detect an odds ratio of 1.4 for this study's 18-week study interval was high (>0.80). The matched case-control study design is widely regarded as appropriate for investigations of rare diseases such as optic neuritis; a case-control design was used by researchers in another large vaccine safety investigation of optic neuritis.1

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