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April 2007

New Therapies for Ataxia-Telangiectasia

Author Affiliations

Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Neurol. 2007;64(4):607-608. doi:10.1001/archneur.64.4.607-b

We read with interest the recent article by Buoni et al1 in which the authors described a striking improvement in the ataxia in a 3-year-old boy with ataxia-telangiectasia (AT) during treatment with inhaled betamethasone. In spite of the favorable response to the drug, the authors expressed their concern about the adverse effects observed during the trial (weight gain and a cushingoid appearance) and about the safety of betamethasone in an already immunocompromised patient.1

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