We have reviewed the interesting comments of Franciotta et al, who propose that MS and NMO may be distinguished by biologic differences in their respective humoral immune responses: oligoclonal banding, anti-aquaporin-4 (AQP-4) specificity, and background polyreactivity. Given the differing views of the authors1- 3 on the distinctness of NMO and MS, as expressed in our recent “Controversies in Neurology” series, understandably we will express somewhat disparate responses to these comments.
Weinshenker B, Galetta S, Bennett J, Kerr D, Frohman EM. More on Multiple Sclerosis and Neuromyelitis Optica—Reply. Arch Neurol. 2007;64(12):1802–1803. doi:10.1001/archneur.64.12.1802-b