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My coauthors and I thank Dr Poser for the interesting comments. We agree with most of these remarks, but we think that they are not applicable to clinical practice. We agree that acute DEM is a different condition compared with MS; however, as Dr Poser says, the 2 diseases are essentially different concerning genetic susceptibility and neuropathological data. If we consider the question to be a clinical point of view, we are not able to use these parameters to distinguished the 2 diseases.
de Seze J. Multiple Sclerosis and Recurrent Disseminated Encephalomyelitis Are Different Diseases—Reply. Arch Neurol. 2008;65(5):672-677. doi:10.1001/archneur.65.5.674-b