My coauthors and I thank Drs Brinar and Habek for their interesting comments. We agree that MDEM, RDEM, DEM, and ADEM may be confusing. However, as stated in our study, we did not have RDEM but only monophasic ADEM, recurrent ADEM (with the same symptoms), and MS. The difference between multiphasic ADEM and MS may be difficult to distinguish, but we did not identify patients with recurrent ADEM.
Second, none of our patients had clinical signs of polyneuropathy, but we did not systematically perform electromyography in them.
de Seze J. Monophasic Acute, Recurrent, and Multiphasic Disseminated Encephalomyelitis and Multiple Sclerosis—Reply. Arch Neurol. 2008;65(5):672-677. doi:10.1001/archneur.65.5.676-a