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We thank Drs Anschel and Romanelli for their thoughts regarding the evolving indications for the treatment of epilepsy with the use of Gamma Knife radiosurgery. We would only add that the groups outlined in their letter and our mutual reviews have yet to be defined by prospective trials. Our National Institutes of Health–supported pilot study was intended to serve as the basis for a prospective study so that specific subgroups of those with mesial temporal lobe epilepsy who would commonly undergo temporal lobectomy could be identified in quantified ways as especially suitable for radiosurgery.
Quigg M, Barbaro NM. Epilepsy and Radiosurgery—Reply. Arch Neurol. 2008;65(8):1135-1137. doi:10.1001/archneur.65.8.1137