A 42-year-old man enrolled in a research study to measure microglial activation using [O-methyl-11C] N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine ([11C]PBR28), an improved positron emission tomography (PET) radioligand. His history included human immunodeficiency virus infection, diabetes, hypertension, hypercholesterolemia, smoking (12 pack-years), and remote use of cocaine and heroin. Medical and neurological examination results were normal except for elevated blood pressure of 157/100 mm Hg. Brain magnetic resonance imaging (MRI) showed occasional foci of mild chronic white matter ischemia but was otherwise unremarkable (Figure, A).
Kreisl WC, Mbeo G, Fujita M, Zoghbi SS, Pike VW, Innis RB, McArthur JC. Stroke Incidentally Identified Using Improved Positron Emission Tomography for Microglial Activation. Arch Neurol. 2009;66(10):1288-1289. doi:10.1001/archneurol.2009.208