A 60-year-old woman with herpes zoster ophthalmicus (HZO) of the right eye was treated with 800 mg of acyclovir 5 times per day for 7 days. There was no significant medical history. She developed reduced vision and ocular pain due to HZO disciform keratouveitis (a central disclike region of corneal edema with focal endothelial deposits of lymphocytes and associated mild uveitis) in the right eye, which was treated with topical prednisolone acetate, 1%, 4 times daily. The topical regimen was tapered over 6 weeks, and several attempts were made to stop treatment with all topical corticosteroids in the subsequent months; however, this resulted in reoccurrence of the disciform keratouveitis.
Patel DV, McGhee CNJ. Laser Scanning In Vivo Confocal Microscopy Demonstrating Significant Alteration of Human Corneal Nerves Following Herpes Zoster Ophthalmicus. Arch Neurol. 2010;67(5):640-641. doi:10.1001/archneurol.2010.62