Two years ago, Newmark and Newmark1 hypothesized that insufficient vitamin D could play a role in the pathogenesis of Parkinson disease (PD). The study by Knekt et al2 in this issue of the Archives is the first longitudinal analysis of vitamin D status as a risk of incident PD and examines a cohort of more than 3000 participants from the Mini-Finland Health Survey. As an important logical progression from previous epidemiological and animal studies of vitamin D and PD, Knekt and colleagues' study begins to address some of the questions posed by Newmark and Newmark.1 Furthermore, it provides preliminary data supporting future interventional studies of the role of vitamin D in the pathogenesis of PD.
Evatt ML. Beyond Vitamin StatusIs There a Role for Vitamin D in Parkinson Disease?. Arch Neurol. 2010;67(7):795-797. doi:10.1001/archneurol.2010.123