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A 21-month-old girl was referred for magnetic resonance imaging (MRI) of the brain. She had a history of spastic tetraparesis with predominance on the left side. Conventional MRIs (Figure, A-C) revealed bilateral closed-lip schizencephaly, absence of the septum pellucidum, and abnormally oriented gyri of the right hemisphere. The schizencephalic clefts were typically lined by dysplastic gray matter with uncommon extension to the midline on the right side. Diffusion tensor imaging (Figure, D and E) showed distortion of right-hemispheric white matter fibers and deviation of the left superior longitudinal fascicle. Complete interruption of the right cingulum and the trunk of the corpus callosum was depicted by fiber tracking (Figure, F).
Kau T, Malek M, Teichler J, Kellenberger CJ, Boltshauser E, Scheer I. Diffusion Tensor Imaging at 3 T in Bilateral Schizencephaly With Interruption of the Corpus Callosum. Arch Neurol. 2010;67(12):1531-1532. doi:10.1001/archneurol.2010.311