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April 2011

Dopamine Agonists vs Levodopa in Impulse Control Disorders

Author Affiliations

Author Affiliations: Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland (Dr Grosset); Department of Neurology, Internal Medicine Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (Dr Cardoso); and Reta Lila Weston Institute of Neurological Studies, University College London, Institute of Neurology, London, England (Dr Lee).


Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2011

Arch Neurol. 2011;68(4):544-546. doi:10.1001/archneurol.2011.41

We read with interest Weintraub and colleagues' cross-sectional study of 4 impulse control disorders (ICDs) in Parkinson disease.1 The point prevalence for ICDs was 13.6%. Impulse control disorders were more common in dopamine agonist (DA)–treated patients (17.1%) than all other cases (6.8%; odds ratio, 2.72; P < .001). Known associations with ICDs were found, eg, men, younger onset age, being unmarried, and current smoking. Two findings were new and require detailed consideration.

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