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November 1, 2016, Vol 73, No. 11, Pages 1269-1380

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2016;73(11):1269. doi:10.1001/jamaneurol.2015.2491
Viewpoint

Is a Neurologist Needed to Diagnose Acute Stroke in the Emergency Department?Too Many Cooks Might Spoil the Broth

Abstract Full Text
JAMA Neurol. 2016;73(11):1273-1274. doi:10.1001/jamaneurol.2016.2527

This Viewpoint proposes that acute stroke can be managed in the emergency department without the expertise of a neurologist.

Building Better Systems for StrokeThe Time Is Now

Abstract Full Text
JAMA Neurol. 2016;73(11):1274-1275. doi:10.1001/jamaneurol.2016.3041

This Viewpoint discusses the need to reorganize prehospital triage of stroke patients to stroke centers to improve patient outcome.

Editorial

Association Between Serum Calcium Level and the Size and Expansion of Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2016;73(11):1276-1277. doi:10.1001/jamaneurol.2016.3070

Mechanical Thrombectomy for StrokeHow Distal Can We Go?

Abstract Full Text
JAMA Neurol. 2016;73(11):1277-1278. doi:10.1001/jamaneurol.2016.3359

Expanding the Range of Diagnosable Autoimmune Encephalopathies and Encephalomyelopathies

Abstract Full Text
JAMA Neurol. 2016;73(11):1279-1280. doi:10.1001/jamaneurol.2016.2970

Cerebrospinal Fluid Biomarkers in Postconcussion SyndromeMeasuring Neuronal Injury and Distinguishing Individuals at Risk for Persistent Postconcussion Syndrome or Chronic Traumatic Encephalopathy

Abstract Full Text
JAMA Neurol. 2016;73(11):1280-1282. doi:10.1001/jamaneurol.2016.3169

Cytokines as Potential Biomarkers of Parkinson Disease

Abstract Full Text
JAMA Neurol. 2016;73(11):1282-1284. doi:10.1001/jamaneurol.2016.3335
Original Investigation

Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage

Abstract Full Text
has active quiz
JAMA Neurol. 2016;73(11):1285-1290. doi:10.1001/jamaneurol.2016.2252

This cohort study investigates whether a low serum calcium level is associated with an increase in the extent of bleeding in patients with intracerebral hemorrhage as measured by baseline hematoma volume and risk of hematoma expansion.

Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the Middle Cerebral Artery M2 Segment

Abstract Full Text
JAMA Neurol. 2016;73(11):1291-1296. doi:10.1001/jamaneurol.2016.2773

This pooled cohort study evaluates the safety and effectiveness of endovascular therapy for occlusions of the M2 segment of the middle cerebral artery in patients with ischemic stroke.

Autoimmune Glial Fibrillary Acidic Protein AstrocytopathyA Novel Meningoencephalomyelitis

Abstract Full Text
JAMA Neurol. 2016;73(11):1297-1307. doi:10.1001/jamaneurol.2016.2549

This study describes a novel IgG autoantibody found in serum or cerebrospinal fluid that is specific for a cytosolic intermediate filament protein of astrocytes.

Neurochemical Aftermath of Repetitive Mild Traumatic Brain Injury

Abstract Full Text
has active quiz
JAMA Neurol. 2016;73(11):1308-1315. doi:10.1001/jamaneurol.2016.2038

This study investigates whether persistent symptoms after mTBI are associated with brain injury as evaluated by cerebrospinal fluid biochemical markers for axonal damage and other aspects of central nervous system injury.

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson DiseaseA Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2016;73(11):1316-1324. doi:10.1001/jamaneurol.2016.2742

This meta-analysis quantitatively summarizes data on peripheral inflammatory cytokines in patients with Parkinson disease.

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2016;73(11):1325-1333. doi:10.1001/jamaneurol.2016.3185

This preclinical study determines whether young blood plasma ameliorates pathology and cognition in a mouse model for AD.

Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases

Abstract Full Text
JAMA Neurol. 2016;73(11):1334-1341. doi:10.1001/jamaneurol.2016.3338

This cross-sectional study examines the use of positron emission tomographic imaging in patients with dementia of Lewy bodies and Parkinson disease, with and without cognitive impairment, for determination of neocortical tau pathology.

Efficacy and Safety of Rituximab Therapy in Neuromyelitis Optica Spectrum DisordersA Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2016;73(11):1342-1348. doi:10.1001/jamaneurol.2016.1637

This systematic review and meta-analysis evaluates the efficacy and safety of rituximab therapy in neuromyelitis optica spectrum disorders, considering the potential predictive factors related to patient response to rituximab in this disease.

Review

Genome Editing of Monogenic Neuromuscular DiseasesA Systematic Review

Abstract Full Text
JAMA Neurol. 2016;73(11):1349-1355. doi:10.1001/jamaneurol.2016.3388

This systematic review provides an overview of recent advances in genome-editing technology, the latest applications of the method, and potential clinical applications.

Clinical Implications of Basic Neuroscience Research

Potential of the Antibody Against cis–Phosphorylated Tau in the Early Diagnosis, Treatment, and Prevention of Alzheimer Disease and Brain Injury

Abstract Full Text
JAMA Neurol. 2016;73(11):1356-1362. doi:10.1001/jamaneurol.2016.2027

This review assesses the therapeutic potential of the monoclonal antibody to the unique prolyl isomerase Pin1 in the diagnosis and prevention of Alzheimer disease, traumatic brain injury, and chronic traumatic encephalitis.

Clinical Pathologic Conference

Rapidly Progressive Quadriplegia and Encephalopathy

Abstract Full Text
JAMA Neurol. 2016;73(11):1363-1366. doi:10.1001/jamaneurol.2016.1622

This case report describes a patient with a rapidly progressive diffuse sensory motor axonopathy on serial electrodiagnostic testing and generalized slowing to bilateral periodic lateralized epileptiform discharges on electroencephalogram testing.

Images in Neurology

Encephalomyelitis Associated With Dengue Fever

Abstract Full Text
JAMA Neurol. 2016;73(11):1368. doi:10.1001/jamaneurol.2016.1416

This case report describes a man in his 20s who was admitted with a clinical demyelination syndrome and a recent diagnosis of dengue fever.

Research Letter

Risk of Concussion for Athletes in Contact Sports at Higher Altitude vs at Sea LevelA Meta-analysis

Abstract Full Text
JAMA Neurol. 2016;73(11):1369-1370. doi:10.1001/jamaneurol.2016.0795

This meta-analysis examines the literature on concussion rates for athletes in contact sports at sea level and at a higher altitude.

Chronic Subthreshold Cortical Stimulation to Treat Focal Epilepsy

Abstract Full Text
JAMA Neurol. 2016;73(11):1370-1372. doi:10.1001/jamaneurol.2016.2857

This study reports on 13 patients treated with continuous subthreshold electrical cortical stimulation, which suppressed interictal epileptiform discharges and improved clinical seizures.

Comment & Response

Diffusion Hypoxia and/or Primary Mitochondrial Failure?

Abstract Full Text
JAMA Neurol. 2016;73(11):1372-1373. doi:10.1001/jamaneurol.2016.3260

Diffusion Hypoxia and/or Primary Mitochondrial Failure?—Reply

Abstract Full Text
JAMA Neurol. 2016;73(11):1373. doi:10.1001/jamaneurol.2016.3263

Diagnosing Traumatic Encephalopathy Syndrome

Abstract Full Text
JAMA Neurol. 2016;73(11):1373-1374. doi:10.1001/jamaneurol.2016.2802

Diagnosing Traumatic Encephalopathy Syndrome—Reply

Abstract Full Text
JAMA Neurol. 2016;73(11):1374-1375. doi:10.1001/jamaneurol.2016.3423

Rebound Syndrome in Multiple Sclerosis After Fingolimod Cessation

Abstract Full Text
JAMA Neurol. 2016;73(11):1375. doi:10.1001/jamaneurol.2016.3199

Rebound Syndrome in Multiple Sclerosis After Fingolimod Cessation

Abstract Full Text
JAMA Neurol. 2016;73(11):1375-1376. doi:10.1001/jamaneurol.2016.3507

Rebound Syndrome in Multiple Sclerosis After Fingolimod Cessation—Reply

Abstract Full Text
JAMA Neurol. 2016;73(11):1376. doi:10.1001/jamaneurol.2016.3202
Correction

Error in Figure

Abstract Full Text
JAMA Neurol. 2016;73(11):1376. doi:10.1001/jamaneurol.2016.4732
Book and Media Review

Review of MRI-Negative Epilepsy

Abstract Full Text
JAMA Neurol. 2016;73(11):1377. doi:10.1001/jamaneurol.2016.3698
Obituary

In Memoriam: H. Richard Tyler, MD (1927-2016)

Abstract Full Text
JAMA Neurol. 2016;73(11):1378-1380. doi:10.1001/jamaneurol.2016.3620
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
JAMA Neurol. 2016;73(11):1272. doi:10.1001/jamaneurol.2015.2492
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