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June 2017, Vol 74, No. 6, Pages 625-747

In This Issue of JAMA Neurology


Abstract Full Text
free access
JAMA Neurol. 2017;74(6):625. doi:10.1001/jamaneurol.2016.3999

Enhanced Epilepsy Surveillance and Awareness in the Age of Zika

Abstract Full Text
JAMA Neurol. 2017;74(6):631-632. doi:10.1001/jamaneurol.2017.0215

This Viewpoint argues for enhanced seizure and epilepsy awareness and surveillance in infants with congenital ZIKV exposure.

Common Myths in the Use of Levodopa in Parkinson DiseaseWhen Clinical Trials Misinform Clinical Practice

Abstract Full Text
JAMA Neurol. 2017;74(6):633-634. doi:10.1001/jamaneurol.2017.0348

This Viewpoint discusses the implications of misinterpreted clinical trial data leading to misguided clinical practices.

Challenges to Translation and the Hippocratic Oath by Premature Termination of Spinal Cord Stem Cell–Based Trials

Abstract Full Text
JAMA Neurol. 2017;74(6):635-636. doi:10.1001/jamaneurol.2017.0318

This Viewpoint discusses premature termination of spinal cord injury stem cell–based trials and advocates for clear termination guidelines including an orderly exit plan.


Maternal Obesity and Epilepsy

Abstract Full Text
JAMA Neurol. 2017;74(6):637-639. doi:10.1001/jamaneurol.2017.0119

Are More Young People Having Strokes?—A Simple Question With an Uncertain Answer

Abstract Full Text
JAMA Neurol. 2017;74(6):639-641. doi:10.1001/jamaneurol.2017.0161

Decision Making in AdrenoleukodystrophyWhen Is a Good Outcome Really a Good Outcome?

Abstract Full Text
JAMA Neurol. 2017;74(6):641-642. doi:10.1001/jamaneurol.2017.0095
Original Investigation

Sudden Unexpected Death in Epilepsy Among Patients With Benign Childhood Epilepsy With Centrotemporal Spikes

Abstract Full Text
JAMA Neurol. 2017;74(6):645-649. doi:10.1001/jamaneurol.2016.6126

This case series examines whether cases of benign epilepsy with centrotemporal spikes are present in the North American SUDEP (Sudden Unexpected Death in Epilepsy) Registry.

Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non–Alzheimer Disease Pathophysiology

Abstract Full Text
JAMA Neurol. 2017;74(6):650-659. doi:10.1001/jamaneurol.2016.5349

This longitudinal cohort study examines patterns of neurodegeneration patterns in individuals with β-amyloid peptide–negative suspected non-Alzheimer disease pathophysiology compared with their β-amyloid peptide–positive counterparts.

Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. 2017;74(6):660-667. doi:10.1001/jamaneurol.2016.6179

This cohort study examines the prognostic significance of C-reactive protein in amyotrophic lateral sclerosis.

Maternal Body Mass Index in Early Pregnancy and Risk of Epilepsy in Offspring

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(6):668-676. doi:10.1001/jamaneurol.2016.6130

This population-based study evaluates the incidence of childhood-onset epilepsy in mothers who were overweight or obese during early pregnancy.

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

Abstract Full Text
JAMA Neurol. 2017;74(6):677-685. doi:10.1001/jamaneurol.2017.0357

This study characterizes the transcriptomics of peripheral monocytes in patients with amyotrophic lateral sclerosis.

Clinical Features, Molecular Heterogeneity, and Prognostic Implications in YARS2-Related Mitochondrial Myopathy

Abstract Full Text
JAMA Neurol. 2017;74(6):686-694. doi:10.1001/jamaneurol.2016.4357

This case series study examines the myopathy, lactic acidosis, and sideroblastic anemia associated with YARS2-related mitochondrial disease.

Prevalence of Cardiovascular Risk Factors and Strokes in Younger Adults

Abstract Full Text
JAMA Neurol. 2017;74(6):695-703. doi:10.1001/jamaneurol.2017.0020

This analysis of data from the National Inpatient Sample examines whether stroke hospitalization rates have continued to increase and identifies the prevalence of associated stroke risk factors among younger adults aged 18 to 54 years.

Monitored Anesthesia Care vs Intubation for Vertebrobasilar Stroke Endovascular Therapy

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(6):704-709. doi:10.1001/jamaneurol.2017.0192

This case-control study compares clinical and angiographic outcomes between monitored anesthesia care and general anesthesia in patients presenting with vertebrobasilar occlusion strokes.

Neurocognitive Trajectory of Boys Who Received a Hematopoietic Stem Cell Transplant at an Early Stage of Childhood Cerebral Adrenoleukodystrophy

Abstract Full Text
JAMA Neurol. 2017;74(6):710-717. doi:10.1001/jamaneurol.2017.0013

This cohort study characterizes neurocognitive outcomes of boys with childhood cerebral adrenoleukodystrophy and early-stage cerebral disease who were treated with an allogeneic hematopoietic stem cell transplant and identifies disease- and treatment-related factors associated with long-term functioning.

Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals

Abstract Full Text
JAMA Neurol. 2017;74(6):718-726. doi:10.1001/jamaneurol.2017.0244

This cohort study explores whether amyloid protective factors and Alzheimer disease–pattern neurodegeneration protective factors differ in elderly individuals with Alzheimer disease and identifies midlife risk factors associated with amyloid deposition.

Clinical Aspects of Glucose Transporter Type 1 DeficiencyInformation From a Global Registry

Abstract Full Text
JAMA Neurol. 2017;74(6):727-732. doi:10.1001/jamaneurol.2017.0298

This worldwide patient registry study examines the most common features of glucose transporter type 1 deficiency.

Clinical Pathologic Conference

A Middle-aged Man With Progressive Ophthalmoparesis, Ataxia, and Spastic Paraparesis

Abstract Full Text
JAMA Neurol. 2017;74(6):733-736. doi:10.1001/jamaneurol.2017.0055

This case report describes a 50-year-old man who presented with progressive clumsiness and unsteady gait and whose first symptoms began around age 39 years.

Intractable Epilepsy and Progressive Cognitive Decline in a Young Man

Abstract Full Text
JAMA Neurol. 2017;74(6):737-740. doi:10.1001/jamaneurol.2016.3195

This case report describes adolescent-onset intractable epilepsy associated with myoclonus and neurocognitive decline to dementia in a young man.

JAMA Neurology Clinical Challenge

Multiple Spinal Lesions in an Immunocompetent Young Man

Abstract Full Text
JAMA Neurol. 2017;74(6):741-742. doi:10.1001/jamaneurol.2017.0114

A 30-year-old man was referred with progressive quadriplegia that started from the right lower limb and gradually spread to the upper limb and contralateral side. Cerebrospinal fluid testing revealed pleocytosis, elevated protein concentration, and a decreased glucose level, and magnetic resonance imaging of the cervical spine revealed multiple intramedullary lesions. What is your diagnosis?

Research Letter

Home-Based Trials in Adolescent MigraineA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2017;74(6):744-745. doi:10.1001/jamaneurol.2017.0285

This randomized clinical trial assessed the feasibility of a home-based trial of melatonin vs placebo for adolescent migraine prevention.

Comment & Response

Leptomeningeal Enhancement for Multiple SclerosisAnother Radiological Biomarker for a Relapse?

Abstract Full Text
JAMA Neurol. 2017;74(6):745-746. doi:10.1001/jamaneurol.2017.0123

Managing Patients With Large Ischemic Core—What Is in a Match?

Abstract Full Text
JAMA Neurol. 2017;74(6):746. doi:10.1001/jamaneurol.2017.0168

What Is in a Match?—Reply

Abstract Full Text
JAMA Neurol. 2017;74(6):746-747. doi:10.1001/jamaneurol.2017.0173

Error in Byline

Abstract Full Text
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JAMA Neurol. 2017;74(6):747. doi:10.1001/jamaneurol.2017.1140
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2017;74(6):630. doi:10.1001/jamaneurol.2016.4000