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September 2017, Vol 74, No. 9, Pages 1023-1144

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2017;74(9):1023. doi:10.1001/jamaneurol.2016.4014
Viewpoint

I-SPY 2 Breast Cancer Trial as a Model for Innovation in Alzheimer Disease Therapies

Abstract Full Text
JAMA Neurol. 2017;74(9):1027-1028. doi:10.1001/jamaneurol.2017.1528

This Viewpoint discusses the I-SPY breast cancer trials as a model for the development of therapies for Alzheimer disease.

Increasing Public Health Awareness of and Capacity for Arts-Based Therapy in Medicine

Abstract Full Text
JAMA Neurol. 2017;74(9):1029-1030. doi:10.1001/jamaneurol.2017.1639

This Viewpoint discusses how arts-based medical therapies can improve patient quality of life and health care outcomes.

Contemporary Legal Updates to the Definition of Brain Death in Nevada

Abstract Full Text
JAMA Neurol. 2017;74(9):1031-1032. doi:10.1001/jamaneurol.2017.1636

This Viewpoint discusses Nevada’s revisions to its Uniform Determination of Death Act and the rationales behind them.

On the Brain

“Bad at Faces”—A Prosopagnosic’s Tale

Abstract Full Text
JAMA Neurol. 2017;74(9):1033-1034. doi:10.1001/jamaneurol.2017.1412

Nontraditional Diagnoses in Minority PopulationsWhite Disease, Brown Body

Abstract Full Text
JAMA Neurol. 2017;74(9):1035-1036. doi:10.1001/jamaneurol.2017.1642
Editorial

Patient Care Is All About Stories

Abstract Full Text
JAMA Neurol. 2017;74(9):1042-1043. doi:10.1001/jamaneurol.2017.1472

Impact of Birth Place and Geographic Location on Risk Disparities in Cerebrovascular DiseaseImplications for Future Research

Abstract Full Text
JAMA Neurol. 2017;74(9):1043-1045. doi:10.1001/jamaneurol.2017.1560

Shining (Laser) Light on Traumatic Brain Injury Blood Biomarkers

Abstract Full Text
JAMA Neurol. 2017;74(9):1045-1047. doi:10.1001/jamaneurol.2017.0800
Original Investigation

Recrudescence of Deficits After StrokeClinical and Imaging Phenotype, Triggers, and Risk Factors

Abstract Full Text
JAMA Neurol. 2017;74(9):1048-1055. doi:10.1001/jamaneurol.2017.1668

This crossover cohort, case-control study uses medical records from the Research Patient Data Repository to determine the features, triggers, and risk factors of poststroke recrudescence among patients with a previous stroke.

Association Between Birth in a High Stroke Mortality State, Race, and Risk of Dementia

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(9):1056-1062. doi:10.1001/jamaneurol.2017.1553

This cohort study examines the risk of dementia in individuals who are born in the Stroke Belt but later reside in California.

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

Abstract Full Text
JAMA Neurol. 2017;74(9):1063-1072. doi:10.1001/jamaneurol.2017.0655

This cohort study evaluates the use of phospho-tau levels, total-tau levels, and the phospho tau–total tau ratio as diagnostic and prognostic biomarkers in patients with traumatic brain injury.

Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging

Abstract Full Text
JAMA Neurol. 2017;74(9):1073-1080. doi:10.1001/jamaneurol.2017.1359

This cohort study evaluates the association between plasma total tau level and cognitive decline as well as dementia in cognitively normal individuals.

Prevalence of Intracranial Aneurysm in Women With Fibromuscular DysplasiaA Report From the US Registry for Fibromuscular Dysplasia

Abstract Full Text
JAMA Neurol. 2017;74(9):1081-1087. doi:10.1001/jamaneurol.2017.1333

This study examines the prevalence of intracranial aneurysm in women diagnosed with fibromuscular dysplasia.

Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(9):1088-1096. doi:10.1001/jamaneurol.2017.1200

This cross-sectional study investigates the association between brain metabolism and motor scores of patients with early Huntington disease.

Secular Trends of Amyotrophic Lateral SclerosisThe Piemonte and Valle d’Aosta Register

Abstract Full Text
JAMA Neurol. 2017;74(9):1097-1104. doi:10.1001/jamaneurol.2017.1387

This epidemiologic register-based study examines the 20-year epidemiologic trends of amyotrophic lateral sclerosis in the Piemonte and Valle d’Aosta regions of Italy.

Large Perivascular Spaces Visible on Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of DementiaThe Age, Gene/Environment Susceptibility–Reykjavik Study

Abstract Full Text
JAMA Neurol. 2017;74(9):1105-1112. doi:10.1001/jamaneurol.2017.1397

This study examines whether large perivascular spaces visible on magnetic resonance imaging are associated with progression of the established magnetic resonance imaging markers of small vessel disease, cognitive decline, and increased risk of dementia.

Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport

Abstract Full Text
JAMA Neurol. 2017;74(9):1113-1122. doi:10.1001/jamaneurol.2017.1518

This case-control study conducts whole-exome sequencing to evaluate endolysosomal-related variants and genes in early-onset Alzheimer disease.

Association of Genetic Predisposition With Solitary Schwannoma or Meningioma in Children and Young Adults

Abstract Full Text
JAMA Neurol. 2017;74(9):1123-1129. doi:10.1001/jamaneurol.2017.1406

This cohort study uses the database of the Manchester Centre for Genomic Medicine to analyze lymphocyte DNA of young patients who presented with meningioma or schwannoma before age 25 years.

Review

Zolpidem for the Treatment of Neurologic DisordersA Systematic Review

Abstract Full Text
JAMA Neurol. 2017;74(9):1130-1139. doi:10.1001/jamaneurol.2017.1133

This systematic review synthesizes studies that used zolpidem to treat neurologic disorders.

Research Letter

Cerebrospinal Fluid Examination in Survivors of Ebola Virus Disease

Abstract Full Text
JAMA Neurol. 2017;74(9):1141-1143. doi:10.1001/jamaneurol.2017.1460

This cohort study assesses the role of the central nervous system as a potential reservoir for Ebola virus after initial clinical recovery in a population of patients who survived Ebola virus disease.

Observation

Neutropenia in Patients With Multiple Sclerosis Treated With Alemtuzumab

Abstract Full Text
JAMA Neurol. 2017;74(9):1143-1144. doi:10.1001/jamaneurol.2017.1456

This case series describes alemtuzumab-induced neutropenia in 2 patients with multiple sclerosis.

Correction

Incorrect Number in Figure

Abstract Full Text
free access
JAMA Neurol. 2017;74(9):1144. doi:10.1001/jamaneurol.2017.2049
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2017;74(9):1025. doi:10.1001/jamaneurol.2016.4015
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