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January 1, 2017, Vol 74, No. 1, Pages 5-133

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2017;74(1):5. doi:10.1001/jamaneurol.2016.3974
Viewpoint

The Problem of Funding Off-label Deep Brain StimulationBait-and-Switch Tactics and the Need for Policy Reform

Abstract Full Text
JAMA Neurol. 2017;74(1):9-10. doi:10.1001/jamaneurol.2016.2530

This Viewpoint evaluates off-label use and associated costs of deep brain stimulation.

Editorial

The Effect of Neurological Genomics and Personalized Mitochondrial Medicine

Abstract Full Text
JAMA Neurol. 2017;74(1):11-13. doi:10.1001/jamaneurol.2016.4506

Hepatitis E Virus and Guillain-Barré Syndrome

Abstract Full Text
JAMA Neurol. 2017;74(1):13-15. doi:10.1001/jamaneurol.2016.3651

Lesion Size and Perspective in Acute Ischemic StrokeShades of Gray

Abstract Full Text
JAMA Neurol. 2017;74(1):15-17. doi:10.1001/jamaneurol.2016.4275

An Emerging Role for Imaging White Matter in the Preclinical Risk for Alzheimer DiseaseLinking β-Amyloid to Myelin

Abstract Full Text
JAMA Neurol. 2017;74(1):17-19. doi:10.1001/jamaneurol.2016.4123

Rethinking Outcomes in Leucine-Rich, Glioma-Inactivated 1 Protein Encephalitis“Good” Isn't Good Enough

Abstract Full Text
JAMA Neurol. 2017;74(1):19-21. doi:10.1001/jamaneurol.2016.4538

Rituximab in Treatment-Refractory Myasthenia Gravis

Abstract Full Text
JAMA Neurol. 2017;74(1):21-23. doi:10.1001/jamaneurol.2016.4367

Can Sustained Glia-Mediated Brain Inflammation After Repeated Concussive Brain Injury Be Detected In Vivo?

Abstract Full Text
JAMA Neurol. 2017;74(1):23-25. doi:10.1001/jamaneurol.2016.4539
Original Investigation

Diagnostic Challenges and Clinical Characteristics of Hepatitis E Virus–Associated Guillain-Barré Syndrome

Abstract Full Text
JAMA Neurol. 2017;74(1):26-33. doi:10.1001/jamaneurol.2016.3541

This cohort study assesses the prevalence of hepatitis E virus–associated Guillain-Barré syndrome in a Belgian cohort as well as the clinical spectrum of hepatitis E virus–associated Guillain-Barré syndrome.

Endovascular Treatment for Patients With Acute Stroke Who Have a Large Ischemic Core and Large Mismatch Imaging Profile

Abstract Full Text
JAMA Neurol. 2017;74(1):34-40. doi:10.1001/jamaneurol.2016.3954

This case-control study compares the outcomes of patients following stroke with large baseline ischemic cores on computed tomographic perfusion undergoing endovascular therapy with the outcomes of matched controls who had medical care alone.

Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2017;74(1):41-49. doi:10.1001/jamaneurol.2016.3232

This cohort study assesses alterations in myelin content and decreases in brain longitudinal and transverse relaxation rates as risk factors for Alzheimer disease.

Evaluation of Cognitive Deficits and Structural Hippocampal Damage in Encephalitis With Leucine-Rich, Glioma-Inactivated 1 Antibodies

Abstract Full Text
JAMA Neurol. 2017;74(1):50-59. doi:10.1001/jamaneurol.2016.4226

This cross-sectional study evaluates structural changes noted on neuroimaging and cognitive outcomes in patients with leucine-rich, glioma-inactivated 1 protein encephalitis.

Durability of the Rituximab Response in Acetylcholine Receptor Autoantibody–Positive Myasthenia Gravis

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(1):60-66. doi:10.1001/jamaneurol.2016.4190

This study assesses the response to rituximab in the treatment of patients with refractory acetylcholine receptor autoantibody–positive generalized myasthenia gravis.

Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players

Abstract Full Text
JAMA Neurol. 2017;74(1):67-74. doi:10.1001/jamaneurol.2016.3764

This case-control study aims to measure translocator protein 18 kDa, a marker of activated glial cell response, in a cohort of current and former National Football League players and control participants, and to report measures of white matter integrity.

Female- and Male-Specific Risk Factors for StrokeA Systematic Review and Meta-analysis

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(1):75-81. doi:10.1001/jamaneurol.2016.3482

This systematic review and meta-analysis examines sex-specific risk factors for ischemic stroke, hemorrhagic stroke, any stroke, and stroke mortality.

Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without DementiaInfluence of Cognition and Apolipoprotein E ε4 Genotype

Abstract Full Text
JAMA Neurol. 2017;74(1):82-90. doi:10.1001/jamaneurol.2016.3474

This cross-sectional analysis of findings from the Ginkgo Evaluation of Memory study examines the association between amyloid-β and gait speed in elderly individuals without dementia and assesses the role of cognition and apolipoprotein E ε4 status on this association.

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

Abstract Full Text
JAMA Neurol. 2017;74(1):91-99. doi:10.1001/jamaneurol.2016.4370

This postmortem study evaluates whether alterations in aquaporin-4 expression or loss of perivascular aquaporin-4 localization are associated with cognition and Alzheimer disease in aging brains.

Review

Use of Magnetic Resonance Imaging to Visualize Leptomeningeal Inflammation in Patients With Multiple SclerosisA Review

Abstract Full Text
JAMA Neurol. 2017;74(1):100-109. doi:10.1001/jamaneurol.2016.4237

This review evaluates the current status and future prospects regarding the noninvasive detection of cortically based leptomeningeal infiltrates with high-resolution gadolinium contrast-enhanced imaging in patients with multiple sclerosis.

Clinical Implications of Basic Neuroscience Research

Association of Mutations in TBK1 With Sporadic and Familial Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Abstract Full Text
JAMA Neurol. 2017;74(1):110-113. doi:10.1001/jamaneurol.2016.3712

This review discusses the pathogenicity of variants that affect protein levels of TBK1, the gene associated with amyotrophic lateral sclerosis and frontotemporal dementia.

Clinical Pathologic Conference

A 63-Year-Old Man With Progressive Visual Symptoms

Abstract Full Text
JAMA Neurol. 2017;74(1):114-118. doi:10.1001/jamaneurol.2016.2210

This case report describes a 63-year-old man with a 4-year history of insidious onset and gradual progression of visual symptoms.

Images in Neurology

Imaging the Acute Formation of a Cortical Microbleed in Cerebral Amyloid Angiopathy

Abstract Full Text
JAMA Neurol. 2017;74(1):120-121. doi:10.1001/jamaneurol.2016.3445

This case report shows imaging of cortical microbleeds in cerebral amyloid angiopathy over a 5-year period.

Research Letter

Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers

Abstract Full Text
JAMA Neurol. 2017;74(1):122-125. doi:10.1001/jamaneurol.2016.4406

This study investigates whether cerebrospinal fluid ferritin level combine with established Alzheimer disease risk variables in predicting cognitive decline over 7 years in the preclinical phase.

Use of Genetic Testing in Amyotrophic Lateral Sclerosis by Neurologists

Abstract Full Text
JAMA Neurol. 2017;74(1):125-126. doi:10.1001/jamaneurol.2016.4540

This survey of clinical researchers reports the prevalence of genetic testing in amyotrophic lateral sclerosis, which genes are sought, and attitudes toward genetic testing and counseling.

Observation

Pallidal Deep Brain Stimulation for the Treatment of Levodopa-Responsive Juvenile Dystonia and Parkinsonism Secondary to SPG11 Mutation

Abstract Full Text
has multimedia
JAMA Neurol. 2017;74(1):127-128. doi:10.1001/jamaneurol.2016.4297

This case report describes pallidal deep brain stimulation used to treat levodopa-responsive juvenile dystonia and parkinsonism in a patient with a spatacsin gene mutation.

Comment & Response

Association of Cardiovascular Risk Factors and Stroke With Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2017;74(1):128-129. doi:10.1001/jamaneurol.2016.4381

Association of Cardiovascular Risk Factors and Stroke With Alzheimer Disease—Reply

Abstract Full Text
JAMA Neurol. 2017;74(1):129-130. doi:10.1001/jamaneurol.2016.4384

Intra-arterial Treatment for Basilar Artery Occlusion

Abstract Full Text
JAMA Neurol. 2017;74(1):130. doi:10.1001/jamaneurol.2016.4810

Intra-arterial Treatment for Basilar Artery Occlusion—Reply

Abstract Full Text
JAMA Neurol. 2017;74(1):130-131. doi:10.1001/jamaneurol.2016.4870
Obituary

In Memoriam: Donald H. Gilden, MD (1937-2016)

Abstract Full Text
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JAMA Neurol. 2017;74(1):132-133. doi:10.1001/jamaneurol.2016.4634
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2017;74(1):7. doi:10.1001/jamaneurol.2016.3975
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