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In This Issue of JAMA Neurology
Jan 2013

In This Issue of JAMA Neurology

JAMA Neurol. 2013;70(1):10-11. doi:10.1001/jamaneurol.2013.1023

Deng and colleagues provide a systematic review of the clinical, pathological, and genetic features of parkinsonian-pyramidal disease and explore the pathogenic relationship between parkinsonian-pyramidal disease and the FBXO7 gene.Article

To determine the effect of latrepirdine on cognition and global function in patients with mild to moderate Huntington disease, the HORIZON Investigators performed a randomized, double-blind, placebo-controlled study of 403 patients at 64 research centers in Australia, Europe, and North America. Cognition and global function were measured at week 26 using the Mini-Mental State Examination and the Clinician Interview–Based Impression of Change, plus carer interview. Article

Saidha and colleagues conducted a cross-sectional study to determine the relationships between conventional and segmentation-derived optical coherence tomography retinal layer thickness measures with intracranial volume and brain substructure volumes in multiple sclerosis (MS). The study involved 84 patients with MS and 24 healthy control subjects.ArticleEditorial perspective is provided by Ari J. Green, MD, MCRArticle.

McKeon et al determine whether glycine receptor α1 subunit-specific autoantibodies (GlyRα1-IgG) occur in a broader spectrum of brainstem and spinal hyperexcitability disorders than the progressive encephalomyelitis with rigidity and myoclonus phenotype. The study involved 81 patients with stiff-man syndrome phenotype, 80 neurologic control subjects, and 20 healthy control subjects. ArticleEditorial perspective is provided by David Pleasure, MDArticle

To investigate the yield of diagnostic tests, neuroimaging findings, and treatment of ischemic strokes in young adults, Ji and colleagues retrospectively reviewed data on 215 consecutive inpatients aged 18 to 45 years with ischemic stroke/transient ischemic attack from their Get with the Guidelines–Stroke database from 2005 through 2010. Article

To test the hypothesis that acute silent cerebral ischemic events are frequent and potentially transient, Quinn and colleagues conducted a cross-sectional and cohort study of children with sickle cell anemia screened by magnetic resonance imaging of the brain. Article

In a retrospective case study, Lo et al determine if a specific intracerebral hemorrhage ratio predicts poor outcome; whether predictors of outcome in adults predict outcome in childhood hemorrhagic stroke; and whether the cause of hemorrhagic stroke predicts outcome.Article

In a retrospective analysis, Hocker et al further characterize the demographics, outcomes, and prognostic factors for refractory status epilepticus.Article

Relationship between days in anesthetic coma and functional outcome. mRS indicates modified Rankin Scale.

Guerreiro et alArticle identify new genes and risk factors associated with frontotemporal dementia.

Deep brain stimulation (DBS) has been used to treat medication-refractory tics in Tourette syndrome. Okun et al studied the efficacy and safety of a scheduled DBS paradigm in 5 patients. Article

In 24 patients with Parkinson disease, Cooper et al performed serial quantitative assessments of bradykinesia during a defined period following cessation of subthalamic nucleus deep brain stimulation (STN DBS). They determined if a correlation exists between clinical characteristics of patients and the washout rate for bradykinesia when STN DBS is discontinued.Article

Prodoehl and coauthors compare differences in functional brain activity between tremor- and nontremor-dominant subtypes of Parkinson disease using functional magnetic resonance imaging. Article

Bullain and coauthors examine the cross-sectional relationship between physical performance and dementia in the oldest old. Article

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