ZlokovicArticle reviews β-amyloid–independent and β-amyloid–dependent cerebrovascular effects of apolipoprotein E as well as isoform-specific interactions of apolipoprotein E with low-density lipoprotein receptor-related protein 1 on brain vascular cells.
To define the incidence of and explore risk factors for seizures and epilepsy in children with spontaneous intracerebral hemorrhage (ICH), Beslow and colleaguesArticle conducted a prospective cohort study of 73 pediatric subjects with spontaneous ICH, including 20 perinatal and 53 childhood subjects. Editorial perspective is provided by Geoffrey L. Heyer, MD, and E. Steve Roach, MDArticle.
Provenzano and colleaguesArticle collected data from the Alzheimer Disease Neuroimaging Initiative public database to determine the impact of white matter hyperintensities and Pittsburgh Compound B positron-emission tomography–derived amyloid positivity on the clinical expression of Alzheimer disease. Editorial perspective is provided by Karen M. Rodrigue, PhDArticle.
Irwin and colleaguesArticle examine evidence for human-to-human transmission of Alzheimer disease, Parkinson disease, and related neurodegenerative disease–associated proteins in cadaveric human growth hormone recipients.
In a retrospective study, Kornek and coauthorsArticle report the use of natalizumab therapy for highly active pediatric multiple sclerosis.
Clinical course of pediatric patients with multiple sclerosis before and during natalizumab (NA) therapy. Patient numbers are given on the left side of the panel. *Patient 17 received interferon beta (IFN) plus methylprednisolone (MP) intravenously every 3 months. GA indicates glatiramer acetate.
To estimate the incidence and prevalence of amyotrophic lateral sclerosis and motor neuron disease for American Indian and Alaska Native people, Gordon and coworkersArticle analyzed electronic records separately for the calendar years 2002-2009 using inpatient and outpatient visit data from the Indian Health Service.
In a retrospective medical record review, Loureiro et alArticle describe the clinical, genetic, and epidemiological features of Portuguese families with autosomal dominant hereditary spastic paraplegias.
Marchant and coauthorsArticle examine the relationship between neuroimaging measures of vascular brain injury and brain β-amyloid deposition and their associations with cognition in elderly individuals.
In This Issue of JAMA Neurology. JAMA Neurol. 2013;70(4):434-435. doi:10.1001/jamaneurol.2013.2187