Filippi and coauthors summarize the features of multiple sclerosis–related cortical pathology and discuss findings from studies using both conventional and modern quantitative magnetic resonance–based techniques for the assessment of cortical damage and dysfunction in patients with multiple sclerosis.
In a 7-month, 2-center, randomized controlled clinical trial, Dorsey and colleagues evaluate the feasibility, effectiveness, and economic benefits of using web-based videoconferencing (telemedicine) to provide specialty care to patients with Parkinson disease in their homes.
Doherty et al investigated whether parkin -linked parkinsonism is a different clinicopathologic entity to Parkinson disease. Editorial perspective is provided by J. Eric Ahlskog, PhD, MD..
In a population-based cohort, Pedersen et al evaluated the incidence of mild cognitive impairment and its progression to dementia during a 3-year study in 182 patients with Parkinson disease. Editorial perspective is provided by Brian J. Copeland, MD and Mya C. Schiess, MD.
In a cross-sectional study, Ju et al test whether Aβ deposition in preclinical Alzheimer disease, prior to the appearance of cognitive impairment, is associated with changes in quality or quantity of sleep.
Prevalence of amyloid deposition by sleep efficiency group. Participants were grouped by sleep efficiency, at cutoffs of less than 75% and more than 89% for poor and good sleep efficiency, respectively. The proportion in each group with abnormal β-amyloid 42 (Aβ42) level (≤500 pg/mL) decreases with better sleep efficiency. The group with worst sleep efficiency compared with best sleep efficiency had an odds ratio of 5.6 (95% CI, 0.965-32.5) of having amyloid deposition (P = .06).
Handoko and colleagues investigated 2 specific amyloid-β (Aβ) oligomers, Aβ trimers and Aβ*56, in human cerebrospinal fluid (CSF); evaluated the effects of aging and Alzheimer disease; and aimed to obtain support for the hypothesis that they may be pathogenic by determining their relationships to CSF tau.
In a cross-sectional study, Rodrigue et al investigate risk factors for β-amyloid deposition in cognitively healthy middle-aged and older adults.
Lee et al perform whole-exome sequencing to determine the relationship between hereditary motor and sensory neuropathy with proximal dominance and a mutation in the TRK-fused gene in a Korean family.
Erten-Lyons et al examine the association between brain atrophy during life and neuropathology in an elderly population.
In a prospective longitudinal cohort study, Mistry and coauthors assess the diagnostic value of visualizing central veins in brain lesions with magnetic resonance imaging for patients with possible multiple sclerosis for which a diagnosis is uncertain.
Gelfand and colleagues conducted an observational, retrospective study to establish whether microcystic inner nuclear layer abnormalities occur in neuromyelitis optica.
In This Issue of JAMA Neurology. JAMA Neurol. 2013;70(5):547-548. doi:10.1001/jamaneurol.2013.76