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Editorial
April 2015

Circuits and Circuit Disorders: Approaches to NeuromodulationCall for Papers and New Initiative With the American Neurological Association and the Annals of Neurology

Author Affiliations
  • 1Department of Neurology, University of Texas Southwestern Medical Center, Dallas
  • 2Editor, JAMA Neurology
  • 3Department of Neurology, University of Michigan Health System, Ann Arbor
  • 4Past President, American Neurological Association
  • 5Editorial Board Member, JAMA Neurology and Annals of Neurology
JAMA Neurol. 2015;72(4):385. doi:10.1001/jamaneurol.2015.0117

The American Neurological Association (ANA) will host the satellite symposium “Circuits and Circuit Disorders: Approaches to Neuromodulation” on Saturday evening, September 26, 2015, in Chicago, Illinois, the evening before the start of the regular scientific program. The symposium is cosponsored by the Annals of Neurology and JAMA Neurology and will be cochaired by the respective editors, Clifford Saper, MD, PhD, and Roger N. Rosenberg, MD. We are pleased with this new relationship and look forward in future years to developing educational programs with the ANA, the Annals of Neurology, and JAMA Neurology.

The program features Mahlon DeLong, MD, Emory University, 2014 Lasker-DeBakey Clinical Medical Research Award recipient, for his research in developing deep brain stimulation (DBS); Philip Starr, MD, PhD, University of California, San Francisco; Jonathan Mink, MD, PhD, University of Rochester Medical Center; Helen Mayberg, MD, Emory University; and Bryan L. Roth, PhD, University of North Carolina.

The scientific program for the symposium represents a comprehensive review of DBS for Parkinson disease since its inception and development by Dr DeLong and his colleagues, followed by comprehensive presentations of the dystonias, Tourette syndrome, obsessive-compulsive disorder, depression, and chemogenetics using designer receptors exclusively activated by designer drugs (DREADDs).

Dr DeLong will review the concepts of circuits, circuit disorders, and associated neurological signs and symptoms. He will emphasize that the introduction of high-frequency DBS more than 2 decades ago, first for tremor and then for Parkinson disease, has led to a renaissance in functional stereotaxic surgery for movement disorders as well as for a wide variety of other neurological and psychiatric disorders. Dr DeLong maintains that DBS is not disease specific but rather circuit specific, since the same target may be used to treat a variety of movement disorders.1,2

Dr Starr will present his work on circuit mechanisms of dystonia using combined cortical and basal ganglia recordings in humans undergoing DBS. He will present his findings that support the view that generalized dystonia and Parkinson disease may have physiologic overlap with respect to motor cortex synchronization and resting-state activity.

Dr Mink’s presentation will focus on the results of recent studies of DBS in Tourette syndrome and obsessive-compulsive disorder, current controversies, and emerging directions, while Dr Mayberg will discuss DBS as an emerging experimental treatment strategy for patients with intractable major depression.

Dr Roth will summarize DREADDs, the chemogenetic platform that provides remote control of neuronal activity in a cell type–specific and noninvasive manner. He will then highlight applications of this technology as a therapeutic approach for a variety of neurological disorders and how chemogenetic technologies induce the sequential multimodal control of neurons in freely moving animals.

JAMA Neurology welcomes manuscripts submitted to us on these subjects by May 1, 2015, so that they can be peer reviewed in the standard manner and be published as an Online First article during the same month as the symposium and subsequently in print as a Theme Issue on “Circuits and Circuit Disorders: Approaches to Neuromodulation.”

Registration for the ANA meeting and a hotel reservation can be obtained by going to http://myana.org/events/ana-2015-annual-meeting.

This symposium is the prologue to an excellent scientific program of the 140th Annual Meeting of the ANA. We hope you will begin this outstanding educational opportunity provided by the ANA by attending this symposium and experiencing a first-rate scientific discussion on neuromodulation and the anticipated future developments in this dynamic and rapidly emerging field of neurology.

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Article Information

Corresponding Author: Roger N. Rosenberg, MD, Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9108 (roger.rosenberg@utsouthwestern.edu).

Published Online: March 2, 2015. doi:10.1001/jamaneurol.2015.0117.

Conflict of Interest Disclosures: None reported.

References
1.
DeLong  MR, Benabid  AL.  Discovery of high-frequency deep brain stimulation for treatment of Parkinson disease: 2014 Lasker Award. JAMA. 2014;312(11):1093-1094.
PubMedArticle
2.
Rousseaux  MWC, Zoghbi  HY.  Deep brain stimulation for Parkinson disease: the 2014 Lasker-DeBakey Clinical Medical Research Award [published online January 5, 2015]. JAMA Neurol. doi:10.1001/jamaneurol.2014.4109.
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