Ahmed and colleagues define the severity of abnormal eating behavior and sucrose preference and their neural correlates in patients with behavioral variant frontotemporal dementia (bvFTD) and semantic dementia. Forty-nine patients with dementia (19 with bvFTD, 15 with semantic dementia, and 15 with Alzheimer disease) were recruited, and their eating behavior was compared with that of 25 healthy controls. The authors report that marked hyperphagia is restricted to bvFTD, present in all patients with this diagnosis, and supports its diagnostic value. Editorial perspective is provided by Jennifer L. Whitwell, PhD.
Teoh and colleagues further characterize enterovirus 71 (EV71)–related neurological disease and neurological outcome in children using a prospective 2-hospital (The Sydney Children’s Hospitals Network) inpatient study of 61 children with enterovirus-related neurological disease during a 2013 outbreak of EV71 in Sydney, Australia. They found that EV71 may cause serious neurological disease in young patients and that the distinct clinicoradiological syndromes, predominantly within the spinal cord and brainstem, enable rapid recognition within evolving outbreaks.
Kumar and coauthors describe the clinical presentations and neuroimaging findings in a subset of patients with intracerebral hemorrhage (ICH) presenting with transient neurological signs and symptoms. A hospital database of a large academic center in Boston, Massachusetts, was searched using International Classification of Diseases, Ninth Revision code 431 from June 1, 2000, to August 31, 2014, to identify patients with ICH who had transient deficits that resolved completely within 24 hours of symptom onset. The authors found that patients with ICH can present with rapidly resolving deficits resembling transient ischemic attacks.
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Wills and colleagues explore the association between change in body mass index (BMI), Unified Parkinson’s Disease Rating Scale (UPDRS) motor and total scores, and survival among persons with Parkinson disease (PD) and test whether there is a positive association between BMI at randomization and survival. By secondary analysis (from May 27, 2014, to October 13, 2015) of longitudinal data (3-6 years) from 1673 participants who started the National Institute of Neurological Disorders and Stroke Exploratory Trials in PD Long-term Study-1 (NET-PD LS-1), they found that change in BMI was inversely associated with change in motor and total UPDRS scores in the NET-PD LS-1 and that change in BMI was not associated with survival.
Highlights. JAMA Neurol. 2016;73(3):251. doi:10.1001/jamaneurol.2015.2443