There have been major advances in our understanding of the neurobiology of depression. The roles of the monoamines, serotonin, and norepinephrine have remained a focus. However, given the complexity of these systems, more refined hypotheses have been developed. In addition, it has become more clear that other neurotransmitter systems, neuropeptides, and intracellular molecular mechanisms may be equally or even more important in the etiology and treatment of depression. This presentation will update the audience on recent findings pertaining to these areas. Possible new approaches to the treatment of depression based upon this work will be presented.
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