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January 2017 - July 1959

Decade

Year

Issue

February 1, 2017, Vol 74, No. 2, Pages 1-249

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2017;74(2):137. doi:10.1001/jamaneurol.2016.3979
Viewpoint

Progress in EpilepsyLatest Waves of Discovery

Abstract Full Text
JAMA Neurol. 2017;74(2):139-140. doi:10.1001/jamaneurol.2016.2967

This Viewpoint discusses recent advances in the understanding of seizure disorders and future pathways of discovery for the treatment of epilepsy.

Dementia Research—A Roadmap for the Next Decade

Abstract Full Text
JAMA Neurol. 2017;74(2):141-142. doi:10.1001/jamaneurol.2016.5004

This Viewpoint discusses where dementia research dementia research should be in 10 years and what we need to do to get there.

Editorial

Looking Toward the Future With You

Abstract Full Text
has multimedia
JAMA Neurol. 2017;74(2):1-2. doi:10.1001/jamaneurol.2016.5607

A New Standard for the Laboratory Diagnosis of Sporadic Creutzfeldt-Jakob Disease

Abstract Full Text
JAMA Neurol. 2017;74(2):144-145. doi:10.1001/jamaneurol.2016.4877

Conformation-Specific Detection of α-SynucleinThe Search for a Biomarker in Parkinson Disease

Abstract Full Text
JAMA Neurol. 2017;74(2):146-147. doi:10.1001/jamaneurol.2016.4813

Selective Serotonin Reuptake Inhibitors and Intracranial HemorrhageDeriving Clinical Relevance From an Epidemiologic Association

Abstract Full Text
JAMA Neurol. 2017;74(2):148-149. doi:10.1001/jamaneurol.2016.5031

Interpreting Periodic and Rhythmic Electroencephalographic Patterns in Critically Ill Patients

Abstract Full Text
JAMA Neurol. 2017;74(2):150-151. doi:10.1001/jamaneurol.2016.5033

Is Serum Albumin Associated With Guillain-Barré Syndrome Outcomes?

Abstract Full Text
JAMA Neurol. 2017;74(2):151-153. doi:10.1001/jamaneurol.2016.4625

OpicaponeA Novel Adjunct for an Old Standard

Abstract Full Text
JAMA Neurol. 2017;74(2):153-154. doi:10.1001/jamaneurol.2016.5012
Original Investigation

Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(2):155-162. doi:10.1001/jamaneurol.2016.4614

This case-control study assesses an algorithm for diagnosis of Creutzfeldt-Jakob disease using cerebrospinal fluid and olfactory mucosa samples among patients with possible, probable, or suspected disease.

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

Abstract Full Text
JAMA Neurol. 2017;74(2):163-172. doi:10.1001/jamaneurol.2016.4547

This study uses cerebrospinal fluid samples from patients with Parkinson disease to develop an assay for diagnosis of Parkinson disease.

Association of Selective Serotonin Reuptake Inhibitors With the Risk for Spontaneous Intracranial Hemorrhage

Abstract Full Text
JAMA Neurol. 2017;74(2):173-180. doi:10.1001/jamaneurol.2016.4529

This population-based cohort study assesses the risk for intracranial hemorrhage associated with the use of selective serotonin reuptake inhibitors among new users of antidepressants and according to the strength of inhibition of serotonin reuptake.

Association of Periodic and Rhythmic Electroencephalographic Patterns With Seizures in Critically Ill Patients

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(2):181-188. doi:10.1001/jamaneurol.2016.4990

This cohort study analyzes the association between periodic and rhythmic pattern frequency and increased risk for seizures in critically ill patients.

Association of Albumin Levels With Outcome in Intravenous Immunoglobulin–Treated Guillain-Barré Syndrome

Abstract Full Text
JAMA Neurol. 2017;74(2):189-196. doi:10.1001/jamaneurol.2016.4480

This cohort study assesses the association between serum albumin levels and the clinical course and outcome of Guillain-Barré syndrome in patients treated with intravenous immunoglobulin.

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor FluctuationsA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2017;74(2):197-206. doi:10.1001/jamaneurol.2016.4703

This randomized clinical trial assesses the efficacy and safety of opicapone as adjunct to levodopa therapy in patients with Parkinson disease experiencing end-of-dose motor fluctuations.

Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System

Abstract Full Text
JAMA Neurol. 2017;74(2):207-215. doi:10.1001/jamaneurol.2016.4202

This study examines the associations between β-amyloid kinetics, age, amyloid, and the β-amyloid day/night pattern in older adults.

Assessment of Safety and Efficacy of Safinamide as a Levodopa Adjunct in Patients With Parkinson Disease and Motor FluctuationsA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2017;74(2):216-224. doi:10.1001/jamaneurol.2016.4467

This randomized clinical trial investigates the efficacy and safety of safinamide (an oral aminoamide derivative with dopaminergic and nondopaminergic actions) as compared with placebo in levodopa-treated patients with motor fluctuations.

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2017;74(2):225-232. doi:10.1001/jamaneurol.2016.3783

This study analyzes the association between exposure to statins and Alzheimer disease risk among Medicare beneficiaries.

Review

Recommendations for the Treatment of Patients With Parkinson Disease During Ramadan

Abstract Full Text
JAMA Neurol. 2017;74(2):233-237. doi:10.1001/jamaneurol.2016.4291

This narrative review provides an overview of options for adapting treatment for patients with Parkinson disease who fast during Ramadan.

Clinical Pathologic Conference

Gradually Progressive Spastic Ataxia in a Young ManSteadily Unsteady

Abstract Full Text
JAMA Neurol. 2017;74(2):238-241. doi:10.1001/jamaneurol.2016.1581

This case report describes a 26-year-old man with mild cerebellar and noticeable thoracic spinal cord atrophy.

Images in Neurology

Top of the Basilar Syndrome Presenting With Convulsions

Abstract Full Text
JAMA Neurol. 2017;74(2):248-249. doi:10.1001/jamaneurol.2016.3449

This case report describes a man in his 60s with impaired level of alertness, convulsive-like movements of the limbs, and vertical nystagmus.

JAMA Neurology Clinical Challenge

Cerebellar Ataxia and Hearing Impairment

Abstract Full Text
JAMA Neurol. 2017;74(2):243-244. doi:10.1001/jamaneurol.2016.3426

A 51-year-old man presented with progressive difficulty walking and deciphering speech. One month later, he required a wheelchair, declined cognitively, and developed personality changes and seizures, eventually becoming completely mute. What is your diagnosis?

Personality Changes, Executive Dysfunction, and Motor and Memory Impairment

Abstract Full Text
JAMA Neurol. 2017;74(2):245-246. doi:10.1001/jamaneurol.2016.2782

A 21-year-old woman presented with a 3-year history of progressive depression, bradyphrenia, dyscalculia, and fatigue, necessitating withdrawal from college. What is your diagnosis?

JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2017;74(2):138. doi:10.1001/jamaneurol.2016.3980
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