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January 2017 - July 1959

Decade

Year

Issue

December 1, 2012, Vol 69, No. 12, Pages 1540-1662

Editorial

Families With Parkinson Disease and Cancer

Abstract Full Text
Arch Neurol. 2012;69(12):1549-1550. doi:10.1001/archneurol.2012.2664

The (Mis)diagnosis of Creutzfeldt-Jakob Disease

Abstract Full Text
Arch Neurol. 2012;69(12):1554-1555. doi:10.1001/2013.jamaneurol.1
Original Contribution

Shared Predispositions of Parkinsonism and CancerA Population-Based Pedigree-Linked Study

Abstract Full Text
free access
Arch Neurol. 2012;69(12):1572-1577. doi:10.1001/archneurol.2012.2261

Kareus and colleagues used a computerized genealogy for Utah pioneers and their descendants linked to a statewide cancer registry and death certificates to estimate relative risks for cancer in individuals with Parkinson disease listed on their death certificate and among their first-degree, second-degree, and third-degree relatives. Walter A. Rocca, MD, MPH, provides an accompanying editorial.

Differential Diagnosis of Jakob-Creutzfeldt Disease

Abstract Full Text
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Arch Neurol. 2012;69(12):1578-1582. doi:10.1001/2013.jamaneurol.79

In a retrospective medical record review, Paterson et al identify the misdiagnoses of patients with sporadic Jakob-Creutzfeldt disease during the course of disease and determine which medical specialties saw these patients prior to the correct diagnosis being made and at what point in the disease course a correct diagnosis was made. See the related editorial by Caselli.

Investigation of C9orf72 in 4 Neurodegenerative Disorders

Abstract Full Text
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Arch Neurol. 2012;69(12):1583-1590. doi:10.1001/archneurol.2012.2016

Using a 2-step genotyping strategy, Xi et al estimate the allele frequency of C9orf72 (G4C2) repeats in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, Alzheimer disease, and Parkinson disease.

β-Amyloid Dynamics in Human Plasma

Abstract Full Text
free access
Arch Neurol. 2012;69(12):1591-1597. doi:10.1001/archneurol.2012.18107

In a repeated plasma and cerebrospinal fluid sampling study, Huang et al investigate dynamic changes in human plasma β-amyloid concentrations, evaluate the effects of aging and amyloidosis on these dynamics, and determine their correlation with cerebrospinal fluid β-amyloid concentrations.

Adult-Onset Opsoclonus-Myoclonus Syndrome

Abstract Full Text
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Arch Neurol. 2012;69(12):1598-1607. doi:10.1001/archneurol.2012.1173

Klaas et al evaluate 21 adults with opsoclonus-myoclonus syndrome (OMS) and review the literature to contribute to the sparse data available on adult-onset OMS.

“Unequivocally Abnormal” vs “Usual” Signs and Symptoms for Proficient Diagnosis of Diabetic PolyneuropathyCl vs N Phys Trial

Abstract Full Text
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Arch Neurol. 2012;69(12):1609-1614. doi:10.1001/archneurol.2012.1481

After a previous trial resulted in inaccurate assessment of diabetic sensorimotor polyneuropathy, Dyck et al used more specific diagnostic criteria and compared findings with nerve conduction studies.

Stroke From Acute Cervical Internal Carotid Artery OcclusionTreatment Results and Predictors of Outcome

Abstract Full Text
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Arch Neurol. 2012;69(12):1615-1620. doi:10.1001/archneurol.2012.2569

To describe the outcomes of intravenous thrombolysis or endovascular treatment in patients with stroke from acute cervical internal carotid artery occlusion, Seet and colleagues performed among 21 patients a retrospective study of the associations of vascular predictor variables with favorable functional recovery at 90 days after stroke.

Regional White Matter Hyperintensity Volume, Not Hippocampal Atrophy, Predicts Incident Alzheimer Disease in the Community

Abstract Full Text
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Arch Neurol. 2012;69(12):1621-1627. doi:10.1001/archneurol.2012.1527

In a longitudinal community-based epidemiological study of older adults from northern Manhattan, New York, Brickman et al determine whether regional white matter hyperintensities and hippocampal volume predict incident Alzheimer disease.

Cerebral Amyloid Deposition and Serotoninergic Innervation in Parkinson Disease

Abstract Full Text
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Arch Neurol. 2012;69(12):1628-1631. doi:10.1001/archneurol.2012.764

Kotagal et al determine whether serotoninergic system degeneration in Parkinson disease (PD) promotes β-amyloid deposition, using in vivo positron emission tomographic probes of serotonin system integrity and β-amyloid deposition.

Impact of Angiotensin Receptor Blockers on Alzheimer Disease Neuropathology in a Large Brain Autopsy Series

Abstract Full Text
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Arch Neurol. 2012;69(12):1632-1638. doi:10.1001/archneurol.2012.1010

Hajjar and colleagues evaluate the impact of treatment with angiotensin receptor blockers (ARBs) on the neuropathology of Alzheimer disease (AD) in the National Alzheimer Coordinating Center database, which includes aggregated data and brain autopsies from 29 AD centers throughout the United States.

Images in Neurology

Usefulness of Positron Emission Tomography With Fludeoxyglucose F 18 and With Carbon 11–Tagged Methionine in the Diagnosis of Hippocampal Lesions

Abstract Full Text
Arch Neurol. 2012;69(12):1652-1653. doi:10.1001/archneurol.2012.304

Histopathological Characteristics of the “Spot Sign” in Spontaneous Intracerebral Hemorrhage

Abstract Full Text
Arch Neurol. 2012;69(12):1654-1655. doi:10.1001/archneurol.2012.672
Observation

Fulminant Subacute Sclerosing Panencephalitis in an Individual With a Perinatally Acquired Human Immunodeficiency Virus Infection

Abstract Full Text
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Arch Neurol. 2012;69(12):1644-1647. doi:10.1001/archneurol.2012.486

Sivadasan and coauthors describe a case of fulminant subacute sclerosing panencephalitis in a 17-year-old boy with a perinatally acquired human immunodeficiency virus infection.

MPV17 Mutations Causing Adult-Onset Multisystemic Disorder With Multiple Mitochondrial DNA Deletions

Abstract Full Text
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Arch Neurol. 2012;69(12):1648-1651. doi:10.1001/archneurol.2012.405

In their case report, Garone and coauthors identify the cause of an adult-onset multisystemic disease with multiple deletions of mitochondrial DNA.

Book Reviews

Evidence-Based Management of Stroke, 1st ed

Abstract Full Text
Arch Neurol. 2012;69(12):1660-1660. doi:10.1001/2013.jamaneurol.375
Obituary

In Memoriam: Joseph Michael Foley, MD (1916-2012)

Abstract Full Text
Arch Neurol. 2012;69(12):1656-1659. doi:10.1001/2013.jamaneurol.496
This Month in Archives of Neurology

This Month in Archives of Neurology

Abstract Full Text
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Arch Neurol. 2012;69(12):1543-1544. doi:10.1001/archneurol.2011.1489
Neurological Review

Dopa-Responsive Dystonia RevisitedDiagnostic Delay, Residual Signs, and Nonmotor Signs

Abstract Full Text
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Arch Neurol. 2012;69(12):1558-1562. doi:10.1001/archneurol.2012.574

Tadic and colleagues searched the MEDLINE database for patients with clinically typical dopa-responsive dystonia (DRD) and/or guanosine triphosphate cyclohydrolase I (GCH1) gene mutations from 1952 to 2011 and examined a pilot cohort of 23 outpatients with DRD and GCH1 mutations to investigate the delay in diagnosis, residual motor signs, and nonmotor signs of DRD.

Clinical Trials

Substitution Monotherapy With Levetiracetam vs Older Antiepileptic DrugsA Randomized Comparative Trial

Abstract Full Text
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Arch Neurol. 2012;69(12):1563-1571. doi:10.1001/archneurol.2012.2203

Hakami et al determine whether patients who fail their first antiepileptic drug (AED) have better neuropsychiatric and quality-of-life outcomes if substituted to levetiracetam monotherapy compared with a second older AED.

From the Archives

Impact of Delirium on the Course of Alzheimer Disease

Abstract Full Text
Arch Neurol. 2012;69(12):1639-1640. doi:10.1001/archneurol.2012.2703
From JAMA

Sex, Stroke, and Atrial Fibrillation

Abstract Full Text
Arch Neurol. 2012;69(12):1641-1643. doi:10.1001/archneurol.2012.2691
Correspondence

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay in the Time of Next-Generation Sequencing—Reply

Abstract Full Text
Arch Neurol. 2012;69(12):1661-1662. doi:10.1001/2013.jamaneurol.389

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay in the Time of Next-Generation Sequencing

Abstract Full Text
Arch Neurol. 2012;69(12):1661-1662. doi:10.1001/2013.jamaneurol.70
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