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August 2017 - July 1959

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Issue

January 2013, Vol 70, No. 1, Pages 4-134

In This Issue of JAMA Neurology

In This Issue of JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2013;70(1):10-11. doi:10.1001/jamaneurol.2013.1023
Editorial
Original Contribution

Relationships Between Retinal Axonal and Neuronal Measures and Global Central Nervous System Pathology in Multiple Sclerosis

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JAMA Neurol. 2013;70(1):34-43. doi:10.1001/jamaneurol.2013.573

Saidha and colleagues conducted a cross-sectional study to determine the relationships between conventional and segmentation-derived optical coherence tomography retinal layer thickness measures with intracranial volume and brain substructure volumes in multiple sclerosis (MS). The study involved patients with MS and 24 healthy control subjects. CNS indicates central nervous system. Ari J. Green provides a related editorial.

Glycine Receptor Autoimmune Spectrum With Stiff-Man Syndrome Phenotype

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JAMA Neurol. 2013;70(1):44-50. doi:10.1001/jamaneurol.2013.574

McKeon and colleagues explored whether glycine receptor a1 subunit-specific autoantibodies (GlyRa1-IgG) occur in a broader spectrum of brainstem and spinal hyperexcitability disorders than the progressive encephalomyelitis with rigidity and myoclonus phenotype. The study involved 81 patients with stiff-man syndrome (SMS) phenotype. David Pleasure, MD, writes an accompanying editorial.

Ischemic Stroke and Transient Ischemic Attack in Young AdultsRisk Factors, Diagnostic Yield, Neuroimaging, and Thrombolysis

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JAMA Neurol. 2013;70(1):51-57. doi:10.1001/jamaneurol.2013.575

To investigate the yield of diagnostic tests, neuroimaging findings, and treatment of ischemic strokes in young adults, Ji and colleagues retrospectively reviewed data on 215 consecutive inpatients, aged 18 to 45 years, with ischemic stroke/transient ischemic attack (TIA) captured in their Get with the Guidelines– Stroke database from 2005-2010.

Acute Silent Cerebral Ischemic Events in Children With Sickle Cell Anemia

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JAMA Neurol. 2013;70(1):58-65. doi:10.1001/jamaneurol.2013.576

To test the hypothesis that acute silent cerebral ischemic events (ASCIEs) are frequent and potentially transient, Quinn and colleagues conducted a cross-sectional and cohort study of children with sickle cell anemia screened by magnetic resonance imaging of the brain.

Outcomes in Children With Hemorrhagic Stroke

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JAMA Neurol. 2013;70(1):66-71. doi:10.1001/jamaneurol.2013.577

In a retrospective case study, Lo et al determine if a specific intracerebral hemorrhage ratio predicts poor outcome; whether predictors of outcome in adults predict outcome in childhood hemorrhagic stroke; and whether the cause of hemorrhagic stroke predicts outcome.

Predictors of Outcome in Refractory Status Epilepticus

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JAMA Neurol. 2013;70(1):72-77. doi:10.1001/jamaneurol.2013.578

In a retrospective analysis Hocker et al further characterize the demographics, outcomes, and prognostic factors for refractory status epilepticus.

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

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JAMA Neurol. 2013;70(1):78-84. doi:10.1001/jamaneurol.2013.579

Guerreiro et al identify new genes and risk factors associated with frontotemporal dementia.

A Trial of Scheduled Deep Brain Stimulation for Tourette SyndromeMoving Away From Continuous Deep Brain Stimulation Paradigms

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JAMA Neurol. 2013;70(1):85-94. doi:10.1001/jamaneurol.2013.580

Deep brain stimulation (DBS) has been used to treat medication-refractory tics in Tourette syndrome. Okun et al studied the efficacy and safety of a scheduled DBS paradigm in 5 patients.

Association of Deep Brain Stimulation Washout Effects With Parkinson Disease Duration

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JAMA Neurol. 2013;70(1):95-99. doi:10.1001/jamaneurol.2013.581

In 24 patients with Parkinson disease, Cooper et al performed serial quantitative assessments of bradykinesia during a defined period following cessation of subthalamic nucleus deep brain stimulation (STN DBS). They determined if a correlation exists between clinical characteristics of patients and the washout rate for bradykinesia when STN DBS is discontinued.

Differences in Brain Activation Between Tremor- and Nontremor-Dominant Parkinson Disease

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JAMA Neurol. 2013;70(1):100-106. doi:10.1001/jamaneurol.2013.582

Prodoehl and coauthors compare differences in functional brain activity between tremor- and nontremor-dominant subtypes of Parkinson disease using functional magnetic resonance imaging.

Poor Physical Performance and Dementia in the Oldest OldThe 90+ Study

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JAMA Neurol. 2013;70(1):107-113. doi:10.1001/jamaneurol.2013.583

Bullain and coauthors examine the cross-sectional relationship between physical performance and dementia in the oldest-old.

Clinical Pathologic Conference

A 62-Year-Old Man With Fluctuating Neurological Deficits and Skin Lesions

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JAMA Neurol. 2013;70(1):120-124. doi:10.1001/2013.jamaneurol.469

Konikkara and coauthors discuss the approach to the diagnosis of a rapidly progressive multifocal brain disorder for a 62-year-old man with fluctuating neurological deficits and skin lesions.

Images in Neurology

Idiopathic Spinal Cord HerniationFirst Reported Case in a Child

Abstract Full Text
JAMA Neurol. 2013;70(1):125-126. doi:10.1001/jamaneurol.2013.586

Neurologic and Vascular Abnormalities in Klippel-Trenaunay-Weber Syndrome

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JAMA Neurol. 2013;70(1):127-128. doi:10.1001/jamaneurol.2013.587
Observation

Intracranial Aneurysm and Recessive Polycystic Kidney DiseaseThe Third Reported Case

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JAMA Neurol. 2013;70(1):114-116. doi:10.1001/jamaneurol.2013.584

Chalhoub and colleagues report the case of a 21-year-old man with autosomal recessive polycystic kidney disease (PKD), presenting with subarachnoid hemorrhage secondary to a ruptured intracranial aneurysm to highlight the possible association of intracranial aneurysm with autosomal recessive PKD.

Persistent Intrathecal Antibody Synthesis 15 Years After Recovering From Anti– N-methyl-D-aspartate Receptor Encephalitis

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JAMA Neurol. 2013;70(1):117-119. doi:10.1001/jamaneurol.2013.585

Hansen et al describe persistent intrathecal antibody synthesis in a clinically healthy person 15 years after recovering from anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis.

Announcement

New Appointments to the Editorial Board

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JAMA Neurol. 2013;70(1):18. doi:10.1001/jamaneurol.2013.693
Annual Reviewers List

Reviewers Who Completed a Review During 2012

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JAMA Neurol. 2013;70(1):8-9. doi:10.1001/jamaneurol.2013.697
Neurological Review

F-Box Only Protein 7 Gene in Parkinsonian-Pyramidal Disease

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JAMA Neurol. 2013;70(1):20-24. doi:10.1001/jamaneurol.2013.572

Deng et al provide a systematic review of the clinical, pathological, and genetic features of parkinsonian-pyramidal disease and explore the pathogenic relationship between parkinsonian-pyramidal disease and the FBXO7 gene.

Clinical Trials

A Randomized, Double-blind, Placebo-Controlled Study of Latrepirdine in Patients With Mild to Moderate Huntington Disease

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JAMA Neurol. 2013;70(1):25-33. doi:10.1001/2013.jamaneurol.382

To determine the effect of latrepirdine in patients with mild to moderate Huntington disease, the HORIZON investigators performed a randomized, double-blind, placebo-controlled study of 403 patients at 64 research centers in Australia, Europe, and North America. Cognition and global function were measured at week 26 using the MMSE and Clinician Interview–Based Impression of Change, plus carer interview.

Correspondence

Measuring Stroke Care and Quality in Routine Data Sets

Abstract Full Text
JAMA Neurol. 2013;70(1):130-131. doi:10.1001/2013.jamaneurol.129

Something for the Weekend?

Abstract Full Text
JAMA Neurol. 2013;70(1):130. doi:10.1001/jamaneurol.2013.651

Weekend Admissions and Increased Risk for Mortality: Less Urgent Treatments Only?

Abstract Full Text
JAMA Neurol. 2013;70(1):131-133. doi:10.1001/jamaneurol.2013.662

Weekend Admissions and Increased Risk for Mortality: Less Urgent Treatments Only?—Reply

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JAMA Neurol. 2013;70(1):131-133. doi:10.1001/jamaneurol.2013.706

Blood-Based Biomarkers in Alzheimer Disease: Where Are We Now and Where Have We to Go?

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JAMA Neurol. 2013;70(1):133-134. doi:10.1001/2013.jamaneurol.67

Blood-Based Biomarkers in Alzheimer Disease: Where Are We Now and Where Have We to Go?—Reply

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JAMA Neurol. 2013;70(1):133-134. doi:10.1001/jamaneurol.2013.709
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