Haley et al tested the hypothesis that symptoms among Gulf War veterans, such as chronic diarrhea, dizziness, fatigue, and sexual dysfunction, are due to cholinergic autonomic dysfunction. They evaluated outcomes in representative samples meeting a validated case definition of Gulf War illness, with 3 variants and a control group.
Winer and coauthors determine whether the SOD1 protein in cerebral spinal fluid may be a pharmacodynamic marker for antisense oligonucleotide therapy and a disease marker for amyotrophic lateral sclerosis.
In a prospective single-center survey, Zheng et al investigate the relationship between aspirin resistance and clinical and neuroimaging measures of stroke severity in acute stroke patients.
Scalfari et al study a cohort with multiple sclerosis and frequent early attacks to elucidate the relationship among early relapses, onset of progression, and severe disability.
Tsuang and colleagues conducted a genetic case-control study to test for an association between the apolipoprotein E (APOE) ε4 allele and dementias with synucleinopathy.
Klein and colleagues aimed to determine, in patients seropositive for neuronal voltage-gated potassium channel (VGKC) complex autoantibodies, the spectrum of clinical presentations and frequency of leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated proteinlike 2 (CASPR2) as defined antigenic neuronal targets in the VGKC macromolecular complex.
Barros et al document and discuss the broad phenotypic variability in a Portuguese family with cerebellar ataxia, hemiplegic migraine, and related syndromes caused by missense mutation c.1748 (p.R583Q) in the CACNA1A gene.
To test the hypothesis that the degeneration of the substantia nigra pars compacta (SNc) precedes that of the cholinergic basal forebrain (BF) in PD, Ziegler and colleagues performed a matched case-control study among 29 patients with PD (Hoehn and Yahr stages 1-3) and 27 matched healthy control subjects. They used new multispectral structural MR imaging tools to measure the volumes of the SNc and BF.
In their case report, Johnson and coauthors report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.
Gurgel-Giannetti et al review all patients with SCO2 mutations and describe a Brazilian patient with cardioencephalomyopathy carrying compound heterozygous mutations in SCO2, one being the known pathogenic p.E140K mutation and the other a novel 12–base pair deletion at nucleotides 1519 through 1530 (c.1519_1530del).
In a case report, Srijithesh describes a patient who presented with nonfixed swan neck deformity of the fingers and generalized body aches.
Miocinovic et al provide a comprehensive review of deep brain stimulation focusing on movement disorders.
Rudick and colleagues review the history of natalizumab therapy from target molecule discovery through regulatory approval, voluntary suspension, reapproval, and clinical use.
In a comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise, Shulman and coauthors compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease. Also see the editorial by Rosenthal and Dorsey.