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August 2017 - July 1959

Decade

Year

Issue

February 2013, Vol 70, No. 2, Pages 146-274

In This Issue of JAMA Neurology

In This Issue of JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2013;70(2):149-150. doi:10.1001/jamaneurol.2013.1605
Editorial

The Benefits of Exercise in Parkinson Disease

Abstract Full Text
JAMA Neurol. 2013;70(2):156-157. doi:10.1001/jamaneurol.2013.772

Objective Evidence of Autonomic Dysfunction and the Role of Stress in the Gulf War Syndrome

Abstract Full Text
JAMA Neurol. 2013;70(2):158-159. doi:10.1001/jamaneurol.2013.1494
Original Contribution

Cholinergic Autonomic Dysfunction in Veterans With Gulf War IllnessConfirmation in a Population-Based Sample

Abstract Full Text
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JAMA Neurol. 2013;70(2):191-200. doi:10.1001/jamaneurol.2013.596

Haley et al tested the hypothesis that symptoms among Gulf War veterans, such as chronic diarrhea, dizziness, fatigue, and sexual dysfunction, are due to cholinergic autonomic dysfunction. They evaluated outcomes in representative samples meeting a validated case definition of Gulf War illness, with 3 variants and a control group.

SOD1 in Cerebral Spinal Fluid as a Pharmacodynamic Marker for Antisense Oligonucleotide Therapy

Abstract Full Text
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JAMA Neurol. 2013;70(2):201-207. doi:10.1001/jamaneurol.2013.593

Winer and coauthors determine whether the SOD1 protein in cerebral spinal fluid may be a pharmacodynamic marker for antisense oligonucleotide therapy and a disease marker for amyotrophic lateral sclerosis.

Association of Aspirin Resistance With Increased Stroke Severity and Infarct Size

Abstract Full Text
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JAMA Neurol. 2013;70(2):208-213. doi:10.1001/jamaneurol.2013.601

In a prospective single-center survey, Zheng et al investigate the relationship between aspirin resistance and clinical and neuroimaging measures of stroke severity in acute stroke patients.

Early Relapses, Onset of Progression, and Late Outcome in Multiple Sclerosis

Abstract Full Text
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JAMA Neurol. 2013;70(2):214-222. doi:10.1001/jamaneurol.2013.599

Scalfari et al study a cohort with multiple sclerosis and frequent early attacks to elucidate the relationship among early relapses, onset of progression, and severe disability.

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

Abstract Full Text
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JAMA Neurol. 2013;70(2):223-228. doi:10.1001/jamaneurol.2013.600

Tsuang and colleagues conducted a genetic case-control study to test for an association between the apolipoprotein E (APOE) ε4 allele and dementias with synucleinopathy.

Insights From LGI1 and CASPR2 Potassium Channel Complex Autoantibody Subtyping

Abstract Full Text
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JAMA Neurol. 2013;70(2):229-234. doi:10.1001/jamaneurol.2013.592

Klein and colleagues aimed to determine, in patients seropositive for neuronal voltage-gated potassium channel (VGKC) complex autoantibodies, the spectrum of clinical presentations and frequency of leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated proteinlike 2 (CASPR2) as defined antigenic neuronal targets in the VGKC macromolecular complex.

Cerebellar Ataxia, Hemiplegic Migraine, and Related Phenotypes Due to a CACNA1A Missense Mutation12-Year Follow-up of a Large Portuguese Family

Abstract Full Text
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JAMA Neurol. 2013;70(2):235-240. doi:10.1001/jamaneurol.2013.591

Barros et al document and discuss the broad phenotypic variability in a Portuguese family with cerebellar ataxia, hemiplegic migraine, and related syndromes caused by missense mutation c.1748 (p.R583Q) in the CACNA1A gene.

Substantia Nigra Volume Loss Before Basal Forebrain Degeneration in Early Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2013;70(2):241-247. doi:10.1001/jamaneurol.2013.597

To test the hypothesis that the degeneration of the substantia nigra pars compacta (SNc) precedes that of the cholinergic basal forebrain (BF) in PD, Ziegler and colleagues performed a matched case-control study among 29 patients with PD (Hoehn and Yahr stages 1-3) and 27 matched healthy control subjects. They used new multispectral structural MR imaging tools to measure the volumes of the SNc and BF.

From the JAMA Network

Interferon Beta Use and Disability Prevention in Relapsing-Remitting Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2013;70(2):248-251. doi:10.1001/jamaneurol.2013.1017

Scores of Scores

Abstract Full Text
JAMA Neurol. 2013;70(2):252-253. doi:10.1001/jamaneurol.2013.1144
Images in Neurology

Spinal Subdural Abscess

Abstract Full Text
JAMA Neurol. 2013;70(2):266-267. doi:10.1001/jamaneurol.2013.588

Sirsasana (Headstand) Pose Causing Compressive Myelopathy With Myelomalacia

Abstract Full Text
JAMA Neurol. 2013;70(2):268. doi:10.1001/jamaneurol.2013.589
Observation

Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia

Abstract Full Text
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JAMA Neurol. 2013;70(2):254-257. doi:10.1001/2013.jamaneurol.139

In their case report, Johnson and coauthors report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.

Mitochondrial Cardioencephalomyopathy Due to a Novel SCO2 Mutation in a Brazilian PatientCase Report and Literature Review

Abstract Full Text
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JAMA Neurol. 2013;70(2):258-261. doi:10.1001/jamaneurol.2013.595

Gurgel-Giannetti et al review all patients with SCO2 mutations and describe a Brazilian patient with cardioencephalomyopathy carrying compound heterozygous mutations in SCO2, one being the known pathogenic p.E140K mutation and the other a novel 12–base pair deletion at nucleotides 1519 through 1530 (c.1519_1530del).

An Unusual Cause of Swan Neck Deformity of the Fingers

Abstract Full Text
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JAMA Neurol. 2013;70(2):263-265. doi:10.1001/jamaneurol.2013.594

In a case report, Srijithesh describes a patient who presented with nonfixed swan neck deformity of the fingers and generalized body aches.

Obituary

In Memoriam: Dewey K. Ziegler, MD (1920-2012)

Abstract Full Text
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JAMA Neurol. 2013;70(2):269. doi:10.1001/jamaneurol.2013.1206
Neurological Review

History, Applications, and Mechanisms of Deep Brain Stimulation

Abstract Full Text
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JAMA Neurol. 2013;70(2):163-171. doi:10.1001/2013.jamaneurol.45

Miocinovic et al provide a comprehensive review of deep brain stimulation focusing on movement disorders.

NatalizumabBench to Bedside and Beyond

Abstract Full Text
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JAMA Neurol. 2013;70(2):172-182. doi:10.1001/jamaneurol.2013.598

Rudick and colleagues review the history of natalizumab therapy from target molecule discovery through regulatory approval, voluntary suspension, reapproval, and clinical use.

Clinical Trials

Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease

Abstract Full Text
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JAMA Neurol. 2013;70(2):183-190. doi:10.1001/jamaneurol.2013.646

In a comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise, Shulman and coauthors compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease. Also see the editorial by Rosenthal and Dorsey.

Correspondence

Antioxidants for Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2013;70(2):270-271. doi:10.1001/jamaneurol.2013.613

Antioxidants for Alzheimer Disease—Reply

Abstract Full Text
JAMA Neurol. 2013;70(2):270-271. doi:10.1001/jamaneurol.2013.935

Evolution and Animal Models

Abstract Full Text
JAMA Neurol. 2013;70(2):271-272. doi:10.1001/2013.jamaneurol.458

Evolution and Animal Models—Reply

Abstract Full Text
JAMA Neurol. 2013;70(2):271-272. doi:10.1001/jamaneurol.2013.748

What Is the True Clinicopathologic Spectrum of Neuromyelitis Optica?—Reply

Abstract Full Text
JAMA Neurol. 2013;70(2):272-273. doi:10.1001/jamaneurol.2013.1286

What Is the True Clinicopathologic Spectrum of Neuromyelitis Optica?

Abstract Full Text
JAMA Neurol. 2013;70(2):272-273. doi:10.1001/jamaneurol.2013.963

Atrial Fibrillation Associated With Epileptic Seizures

Abstract Full Text
JAMA Neurol. 2013;70(2):273-274. doi:10.1001/jamaneurol.2013.1265

Atrial Fibrillation Associated With Epileptic Seizures—Reply

Abstract Full Text
JAMA Neurol. 2013;70(2):273-274. doi:10.1001/jamaneurol.2013.1268
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