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February 2017 - July 1959

Decade

Year

Issue

December 1, 2016, Vol 73, No. 12, Pages 1385-1504

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2016;73(12):1385. doi:10.1001/jamaneurol.2015.2497
Viewpoint

Emerging Diagnostic and Therapeutic Tools for Central Nervous System Infections

Abstract Full Text
JAMA Neurol. 2016;73(12):1389-1390. doi:10.1001/jamaneurol.2016.3617

This Viewpoint discusses 2 next-generation approaches to diagnosis and therapy that are either already clinically relevant or likely to be tested in central nervous system neurotropic viral infections in the near future.

Editorial

Announcing the New JAMANeurology.com

Abstract Full Text
free access
JAMA Neurol. 2016;73(12):1391-1392. doi:10.1001/jamaneurol.2016.4536

JAMA Neurology at the Forefront, 1997-2016

Abstract Full Text
JAMA Neurol. 2016;73(12):1392-1394. doi:10.1001/jamaneurol.2016.3943

Zika Virus—A Public Health Emergency of International Concern

Abstract Full Text
free access
JAMA Neurol. 2016;73(12):1395-1396. doi:10.1001/jamaneurol.2016.3677

Clinical Impact of Amyloid Positron Emission Tomography—Is It Worth the Cost?

Abstract Full Text
JAMA Neurol. 2016;73(12):1396-1398. doi:10.1001/jamaneurol.2016.3792

Dietary Factors and Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. 2016;73(12):1398-1399. doi:10.1001/jamaneurol.2016.3905

Leukoencephalopathy With Axonal Spheroids and Pigmented GliaNew Clues in Sporadic Cases

Abstract Full Text
JAMA Neurol. 2016;73(12):1400-1401. doi:10.1001/jamaneurol.2016.2940

Risk for Intracerebral Hematoma Expansion—More Than Just the Spot Sign

Abstract Full Text
JAMA Neurol. 2016;73(12):1401-1403. doi:10.1001/jamaneurol.2016.3048

The Clinical Profile of GBA-Related Lewy Body Disorders

Abstract Full Text
JAMA Neurol. 2016;73(12):1403-1404. doi:10.1001/jamaneurol.2016.2546

Deutetrabenazine—Not a Revolution but Welcome Evolution for Treating Chorea in Huntington Disease

Abstract Full Text
JAMA Neurol. 2016;73(12):1404-1406. doi:10.1001/jamaneurol.2016.3916
Original Investigation

Congenital Zika Virus InfectionBeyond Neonatal Microcephaly

Abstract Full Text
free access has active quiz
JAMA Neurol. 2016;73(12):1407-1416. doi:10.1001/jamaneurol.2016.3720

This case series describes the prenatal evolution and perinatal outcomes of 11 neonates who had developmental abnormalities and neurological damage associated with maternal Zika virus infection in Brazil.

Assessment of the Incremental Diagnostic Value of Florbetapir F 18 Imaging in Patients With Cognitive ImpairmentThe Incremental Diagnostic Value of Amyloid PET With [18F]-Florbetapir (INDIA-FBP) Study

Abstract Full Text
JAMA Neurol. 2016;73(12):1417-1424. doi:10.1001/jamaneurol.2016.3751

This multicenter cohort study examines the use of florbetapir F 18 positron emission tomography in the confirmation or change in the diagnosis of Alzheimer disease and other cognitive impairment disorders.

Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis

Abstract Full Text
free access
JAMA Neurol. 2016;73(12):1425-1432. doi:10.1001/jamaneurol.2016.3401

This cross-sectional study evaluates the associations between nutrients, individually and in groups, and amyotrophic lateral sclerosis function and respiratory function at diagnosis.

Analysis of Mutations in AARS2 in a Series of CSF1R-Negative Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

Abstract Full Text
JAMA Neurol. 2016;73(12):1433-1439. doi:10.1001/jamaneurol.2016.2229

This case series describes the features of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and performs genetic sequencing in patients who do not carry CSF1R mutations.

Association of Key Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease With Hematoma Volume and Expansion in Patients With Lobar and Deep Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2016;73(12):1440-1447. doi:10.1001/jamaneurol.2016.2619

This analysis of data collected from consecutive patients admitted with primary lobar or deep intracerebral hemorrhage to a single tertiary care medical center investigates the association between key magnetic resonance imaging markers of small vessel disease and hematoma volume and expansion.

High Frequency of GBA Gene Mutations in Dementia With Lewy Bodies Among Ashkenazi Jews

Abstract Full Text
JAMA Neurol. 2016;73(12):1448-1453. doi:10.1001/jamaneurol.2016.1593

This cross-sectional study assesses the prevalence of GBA gene mutations in Ashkenazi Jews with clinically probable or possible dementia with Lewy bodies, and associations between GBA carrier status and disease severity.

Diagnosing Sporadic Creutzfeldt-Jakob Disease by the Detection of Abnormal Prion Protein in Patient Urine

Abstract Full Text
has active quiz
JAMA Neurol. 2016;73(12):1454-1460. doi:10.1001/jamaneurol.2016.3733

This cross-sectional study assesses the feasibility of sporadic Creutzfeldt-Jakob disease diagnosis by adaptation of an established variant Creutzfeldt-Jakob disease diagnostic blood test to urine.

Risk of Pregnancy-Associated Stroke Across Age Groups in New York State

Abstract Full Text
JAMA Neurol. 2016;73(12):1461-1467. doi:10.1001/jamaneurol.2016.3774

This population-based cohort study uses data from the New York State SPARCS database to examine the risk of stroke in women of childbearing age who are pregnant or post partum compared with the risk in those who are not pregnant.

Association Between Metabolic Syndrome Components and Polyneuropathy in an Obese Population

Abstract Full Text
JAMA Neurol. 2016;73(12):1468-1476. doi:10.1001/jamaneurol.2016.3745

This cross-sectional study examines the prevalence of polyneuropathy stratified by glycemic status in obese and lean participants and investigates the association of specific components of metabolic syndrome with polyneuropathy.

Subregional Pattern of Striatal Dopamine Transporter Loss on 18F FP-CIT Positron Emission Tomography in Patients With Pure Akinesia With Gait Freezing

Abstract Full Text
JAMA Neurol. 2016;73(12):1477-1484. doi:10.1001/jamaneurol.2016.3243

This case-control study investigates the subregional pattern of striatal dopamine transporter loss in patients with pure akinesia with gait freezing in comparison with patients with progressive supranuclear palsy and those with Parkinson disease.

Review

Advances in Sequencing Technologies for Understanding Hereditary AtaxiasA Review

Abstract Full Text
JAMA Neurol. 2016;73(12):1485-1490. doi:10.1001/jamaneurol.2016.3097

This review uses the example of hereditary ataxias to assess the contribution of next-generation sequencing to identification of the genetic basis of neurogenetic syndromes.

Images in Neurology

A Woman With Intellectual Disability, Amenorrhoea, Seizures, and Balance Problems

Abstract Full Text
JAMA Neurol. 2016;73(12):1494-1495. doi:10.1001/jamaneurol.2016.3613

A woman in her 30s with intellectual disability, primary amenorrhoea, and focal seizures described 2 years of progressive difficulties.

Treatment of Carotid Intramural Thrombus With TPA

Abstract Full Text
JAMA Neurol. 2016;73(12):1496. doi:10.1001/jamaneurol.2016.3223

This case report describes the treatment of carotid intramural thrombus with intravenous tissue plasminogen activator.

JAMA Neurology Clinical Challenge

Acute Neck Pain Progressing to Hemiparesis With Brain and Spinal Cord Lesions

Abstract Full Text
JAMA Neurol. 2016;73(12):1491-1492. doi:10.1001/jamaneurol.2016.1365

A man had weakness in the distal right hand and leg; and sudden, severe neck pain that progressed to neck stiffness and shoulder pain; magnetic resonance imaging revealed abnormal signals throughout the brain and a lesion at the level of the fifth cervical vertebra. What is your diagnosis?

Comment & Response

Trends in the Incidence of Parkinson Disease

Abstract Full Text
JAMA Neurol. 2016;73(12):1497. doi:10.1001/jamaneurol.2016.3844

Trends in the Incidence of Parkinson Disease

Abstract Full Text
JAMA Neurol. 2016;73(12):1497-1498. doi:10.1001/jamaneurol.2016.3850

Trends in the Incidence of Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2016;73(12):1498-1499. doi:10.1001/jamaneurol.2016.3847

Plasma Coenzyme Q10 Levels and Multiple System Atrophy

Abstract Full Text
JAMA Neurol. 2016;73(12):1499. doi:10.1001/jamaneurol.2016.4130

Plasma Coenzyme Q10 Levels and Multiple System Atrophy—Reply

Abstract Full Text
JAMA Neurol. 2016;73(12):1499-1500. doi:10.1001/jamaneurol.2016.4133

HLA Genetic Risk Burden in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2016;73(12):1500-1501. doi:10.1001/jamaneurol.2016.4329

HLA Genetic Risk Burden in Multiple Sclerosis—Reply

Abstract Full Text
JAMA Neurol. 2016;73(12):1501-1502. doi:10.1001/jamaneurol.2016.4326

Doubts About Therapy for Neurological Diseases With Antisense Oligonucleotides

Abstract Full Text
JAMA Neurol. 2016;73(12):1502. doi:10.1001/jamaneurol.2016.4332

Doubts About Therapy for Neurological Diseases With Antisense Oligonucleotides—Reply

Abstract Full Text
JAMA Neurol. 2016;73(12):1502-1503. doi:10.1001/jamaneurol.2016.4335
Obituary

In Memoriam: Milton Alter, MD, PhD (1929-2016)

Abstract Full Text
free access
JAMA Neurol. 2016;73(12):1504. doi:10.1001/jamaneurol.2016.4562
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2016;73(12):1387. doi:10.1001/jamaneurol.2015.2498
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