This Viewpoint discusses 2 underused strategies in identifying biomarkers that define multiple sclerosis and argues that they may lead to better therapeutic strategies.
This nested case-control study in the Finnish Maternity Cohort examines whether insufficient D levels in early pregnancy are associated with risk of multiple sclerosis in offspring.
This cohort study evaluates the effects of metformin and pioglitazone on immune regulation in patients with multiple sclerosis and metabolic syndrome and evaluates potential mechanisms underlying this anti-inflammatory effect.
This population-based study examines the association between rosacea and the subsequent development of Parkinson disease in Denmark.
This matched-cohort study uses Veterans Health Administration data to assess whether use of antipsychotics in a population of veterans with Parkinson disease is associated with increased mortality.
This case-control study used fluorine 18–labeled fluoromisonidazole tracer and oxygen 15–labeled positron emission tomography to determine the pathophysiologic mechanisms of cerebral ischemia and diffusion hypoxia in patients with early traumatic brain injury.
This cohort study evaluates the temporal profiles of GFAP and UCH-L1 in a large cohort of trauma patients and assesses their diagnostic accuracy over time for detecting traumatic brain injury, traumatic intracranial lesions on head computed tomography, and neurosurgical intervention.
This study investigates the diagnostic and prognostic utility of cerebrospinal fluid neurogranin levels in a large well-characterized cohort of individuals with symptomatic Alzheimer disease and cognitively normal controls.
This cohort study seeks to determine predictors of early recurrent cerebrovascular events among patients with transient ischemic attacks and minor strokes and National Institutes of Health Stroke Scale scores of 0 to 3.
This case-control study assesses whether obesity is a risk factor for central venous thrombosis.
This study evaluates the incidence of stimulus-induced rhythmic, periodic, or ictal discharges found in prolonged electroencephalographic recordings and their clinical implications in critically ill patients.
This review details the current understanding of the cause of strokelike episodes in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS) and presents recommendations to assist in the identification and treatment of patients with MELAS presenting with stroke.
This case report describes a young man with gradually worsening cognitive decline and left anterior temporal atrophy.
This case report describes a man in his 40s who was admitted after 4 months of progressive leg paresthesias and subjective leg weakness.
A woman in her late 50s was found to have subdural collection as an initial presentation of granulomatosis with polyangiitis.
A man in his 50s presented with a 5-year history of stepwise loss of executive and somato-sensory functions in relation to what was interpreted as 2 previous stroke episodes; he was diagnosed with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.