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January 2017 - July 1959

Decade

Year

Issue

May 1, 2016, Vol 73, No. 5, Pages 493-609

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2016;73(5):493. doi:10.1001/jamaneurol.2015.2455
Viewpoint

Will Biomarkers Determine What Is Next in Multiple Sclerosis?Biomarkers in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2016;73(5):496-497. doi:10.1001/jamaneurol.2015.4841

This Viewpoint discusses 2 underused strategies in identifying biomarkers that define multiple sclerosis and argues that they may lead to better therapeutic strategies.

Editorial

Vitamin D During Pregnancy and Multiple SclerosisAn Evolving Association

Abstract Full Text
JAMA Neurol. 2016;73(5):498-499. doi:10.1001/jamaneurol.2016.0018

Positive Effect on Multiple Sclerosis With Treatment of Metabolic Syndrome

Abstract Full Text
JAMA Neurol. 2016;73(5):499-501. doi:10.1001/jamaneurol.2015.5050

Parkinson Disease Risk in Patients With Rosacea

Abstract Full Text
JAMA Neurol. 2016;73(5):501-502. doi:10.1001/jamaneurol.2016.0291

Antipsychotics and Increased MortalityAre We Sure?

Abstract Full Text
JAMA Neurol. 2016;73(5):502-504. doi:10.1001/jamaneurol.2016.0213

Brain Hypoxia and Ischemia After Traumatic Brain InjuryIs Oxygen the Right Metabolic Target?

Abstract Full Text
JAMA Neurol. 2016;73(5):504-505. doi:10.1001/jamaneurol.2016.0251

Dissecting Temporal Profiles of Neuronal and Axonal Damage After Mild Traumatic Brain Injury

Abstract Full Text
JAMA Neurol. 2016;73(5):506-507. doi:10.1001/jamaneurol.2016.0290

Cerebrospinal Biomarkers in Alzheimer Disease—Potential Roles as Markers of Prognosis and Neuroplasticity

Abstract Full Text
JAMA Neurol. 2016;73(5):508-510. doi:10.1001/jamaneurol.2016.0090

The Challenges of Stroke Prediction Scores

Abstract Full Text
JAMA Neurol. 2016;73(5):510-511. doi:10.1001/jamaneurol.2016.0289

Obesity, Oral Contraceptive Use, and Cerebral Venous Thrombosis in Women

Abstract Full Text
JAMA Neurol. 2016;73(5):512-513. doi:10.1001/jamaneurol.2015.5107

Seeking Balance Between Pain Relief and SafetyCDC Issues New Opioid-Prescribing Guidelines

Abstract Full Text
free access
JAMA Neurol. 2016;73(5):513-514. doi:10.1001/jamaneurol.2016.0535
Original Investigation

Vitamin D Status During Pregnancy and Risk of Multiple Sclerosis in Offspring of Women in the Finnish Maternity Cohort

Abstract Full Text
has active quiz
JAMA Neurol. 2016;73(5):515-519. doi:10.1001/jamaneurol.2015.4800

This nested case-control study in the Finnish Maternity Cohort examines whether insufficient D levels in early pregnancy are associated with risk of multiple sclerosis in offspring.

Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2016;73(5):520-528. doi:10.1001/jamaneurol.2015.4807

This cohort study evaluates the effects of metformin and pioglitazone on immune regulation in patients with multiple sclerosis and metabolic syndrome and evaluates potential mechanisms underlying this anti-inflammatory effect.

Exploring the Association Between Rosacea and Parkinson DiseaseA Danish Nationwide Cohort Study

Abstract Full Text
JAMA Neurol. 2016;73(5):529-534. doi:10.1001/jamaneurol.2016.0022

This population-based study examines the association between rosacea and the subsequent development of Parkinson disease in Denmark.

Association of Antipsychotic Use With Mortality Risk in Patients With Parkinson Disease

Abstract Full Text
has active quiz
JAMA Neurol. 2016;73(5):535-541. doi:10.1001/jamaneurol.2016.0031

This matched-cohort study uses Veterans Health Administration data to assess whether use of antipsychotics in a population of veterans with Parkinson disease is associated with increased mortality.

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury

Abstract Full Text
JAMA Neurol. 2016;73(5):542-550. doi:10.1001/jamaneurol.2016.0091

This case-control study used fluorine 18–labeled fluoromisonidazole tracer and oxygen 15–labeled positron emission tomography to determine the pathophysiologic mechanisms of cerebral ischemia and diffusion hypoxia in patients with early traumatic brain injury.

Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

Abstract Full Text
JAMA Neurol. 2016;73(5):551-560. doi:10.1001/jamaneurol.2016.0039

This cohort study evaluates the temporal profiles of GFAP and UCH-L1 in a large cohort of trauma patients and assesses their diagnostic accuracy over time for detecting traumatic brain injury, traumatic intracranial lesions on head computed tomography, and neurosurgical intervention.

Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2016;73(5):561-571. doi:10.1001/jamaneurol.2016.0086

This study investigates the diagnostic and prognostic utility of cerebrospinal fluid neurogranin levels in a large well-characterized cohort of individuals with symptomatic Alzheimer disease and cognitively normal controls.

Imaging Parameters and Recurrent Cerebrovascular Events in Patients With Minor Stroke or Transient Ischemic Attack

Abstract Full Text
JAMA Neurol. 2016;73(5):572-578. doi:10.1001/jamaneurol.2015.4906

This cohort study seeks to determine predictors of early recurrent cerebrovascular events among patients with transient ischemic attacks and minor strokes and National Institutes of Health Stroke Scale scores of 0 to 3.

Risk of Cerebral Venous Thrombosis in Obese Women

Abstract Full Text
JAMA Neurol. 2016;73(5):579-584. doi:10.1001/jamaneurol.2016.0001

This case-control study assesses whether obesity is a risk factor for central venous thrombosis.

Associated Factors and Prognostic Implications of Stimulus-Induced Rhythmic, Periodic, or Ictal Discharges

Abstract Full Text
JAMA Neurol. 2016;73(5):585-590. doi:10.1001/jamaneurol.2016.0006

This study evaluates the incidence of stimulus-induced rhythmic, periodic, or ictal discharges found in prolonged electroencephalographic recordings and their clinical implications in critically ill patients.

Review

Recommendations for the Management of Strokelike Episodes in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes

Abstract Full Text
JAMA Neurol. 2016;73(5):591-594. doi:10.1001/jamaneurol.2015.5072

This review details the current understanding of the cause of strokelike episodes in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS) and presents recommendations to assist in the identification and treatment of patients with MELAS presenting with stroke.

Clinical Pathologic Conference

A Young Man With Progressive Language Difficulty and Early-Onset Dementia

Abstract Full Text
JAMA Neurol. 2016;73(5):595-599. doi:10.1001/jamaneurol.2016.0246

This case report describes a young man with gradually worsening cognitive decline and left anterior temporal atrophy.

Images in Neurology

Longitudinally Extensive Spinal Cord Lesions Disclosing Occult Systemic Sarcoidosis

Abstract Full Text
JAMA Neurol. 2016;73(5):600-601. doi:10.1001/jamaneurol.2016.0013

This case report describes a man in his 40s who was admitted after 4 months of progressive leg paresthesias and subjective leg weakness.

Subdural Collection as Initial Presentation of Granulomatosis With Polyangiitis

Abstract Full Text
JAMA Neurol. 2016;73(5):602-603. doi:10.1001/jamaneurol.2015.4710

A woman in her late 50s was found to have subdural collection as an initial presentation of granulomatosis with polyangiitis.

Observation

Mitochondrial Encephalomyopathy With Lactic Acidosis and Strokelike Episodes Presenting Before 50 Years of AgeWhen a Stroke Is Not Just a Stroke

Abstract Full Text
JAMA Neurol. 2016;73(5):604-606. doi:10.1001/jamaneurol.2015.5061

A man in his 50s presented with a 5-year history of stepwise loss of executive and somato-sensory functions in relation to what was interpreted as 2 previous stroke episodes; he was diagnosed with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes.

Comment & Response

Reversible Cerebral Vasoconstriction Syndrome vs Posterior Reversible Encephalopathy Syndrome

Abstract Full Text
JAMA Neurol. 2016;73(5):606. doi:10.1001/jamaneurol.2015.5104

Reversible Cerebral Vasoconstriction Syndrome or Posterior Reversible Encephalopathy Syndrome—Reply

Abstract Full Text
JAMA Neurol. 2016;73(5):606-607. doi:10.1001/jamaneurol.2015.5110

Potential Association Between Atrial Fibrillation and Dementia

Abstract Full Text
JAMA Neurol. 2016;73(5):607. doi:10.1001/jamaneurol.2015.5066

Potential Association Between Atrial Fibrillation and Dementia—Reply

Abstract Full Text
JAMA Neurol. 2016;73(5):607-608. doi:10.1001/jamaneurol.2015.5069

Peripheral Causes of Cognitive Motor Dissociation in Patients With Vegetative or Minimally Conscious State

Abstract Full Text
JAMA Neurol. 2016;73(5):608. doi:10.1001/jamaneurol.2016.0140

Peripheral Causes of Cognitive Motor Dissociation in Patients With Vegetative or Minimally Conscious State—Reply

Abstract Full Text
JAMA Neurol. 2016;73(5):608-609. doi:10.1001/jamaneurol.2016.0143
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2016;73(5):494. doi:10.1001/jamaneurol.2015.2456
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