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August 2017 - July 1959

Decade

Year

Issue

May 2017, Vol 74, No. 5, Pages 497-612

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2017;74(5):497. doi:10.1001/jamaneurol.2016.3994
Viewpoint

The Catch-22 of Neuroimaging, Disorders of Consciousness, and End-of-Life Decisions

Abstract Full Text
JAMA Neurol. 2017;74(5):501-502. doi:10.1001/jamaneurol.2016.5994

This Viewpoint discusses medically assisted death in patients with brain injuries in whom functional magnetic resonance imaging that relies on blood oxygen levels in particular brain regions have been used to reveal signals that are interpreted as consciousness.

Editorial

Migraine and the Risk of Carotid Artery Dissection in the IPSYS RegistryAre They Related?

Abstract Full Text
JAMA Neurol. 2017;74(5):503-504. doi:10.1001/jamaneurol.2016.6008

Primary Stroke Centers vs Comprehensive Stroke Centers With Interventional CapabilitiesWhich Is Better for a Patient With Suspected Stroke?

Abstract Full Text
JAMA Neurol. 2017;74(5):504-506. doi:10.1001/jamaneurol.2017.0006

Melanopsin Effects on Pupil ResponsesIs the Eye the Window to the Weary Soul?

Abstract Full Text
free access
JAMA Neurol. 2017;74(5):506-508. doi:10.1001/jamaneurol.2016.5385

Preventing DementiaMany Issues and Not Enough Time

Abstract Full Text
JAMA Neurol. 2017;74(5):508-510. doi:10.1001/jamaneurol.2017.0045

Searching for Neurodegeneration in the Blood of Patients With Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2017;74(5):510-511. doi:10.1001/jamaneurol.2017.0010
Original Investigation

Association Between Migraine and Cervical Artery DissectionThe Italian Project on Stroke in Young Adults

Abstract Full Text
JAMA Neurol. 2017;74(5):512-518. doi:10.1001/jamaneurol.2016.5704

This cohort study examines the association between migraine and ischemic stroke due to cervical artery dissection in young patients with ischemic stroke.

Antioxidant Capacity and Superoxide Dismutase Activity in Adrenoleukodystrophy

Abstract Full Text
JAMA Neurol. 2017;74(5):519-524. doi:10.1001/jamaneurol.2016.5715

This study identifies variations in the levels of antioxidant capacity and superoxide dismutase activity between adrenoleukodystrophy phenotypes in patients with cerebral adrenoleukodystrophy or adrenomyeloneuropathy, heterozygote female carriers, and healthy controls and correlates antioxidant levels with clinical outcome scores to determine a possible predictive value.

Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral SclerosisNeurofilament Light Chain Levels in Definite Subtypes of Disease

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(5):525-532. doi:10.1001/jamaneurol.2016.5398

This study assesses the ability of neurofilament light chain to serve as a diagnostic biomarker in amyotrophic lateral sclerosis and the prognostic value of cerebrospinal fluid neurofilament light chain in patients with amyotrophic lateral sclerosis.

Association of Depression and Treated Depression With Epilepsy and Seizure OutcomesA Multicohort Analysis

Abstract Full Text
JAMA Neurol. 2017;74(5):533-539. doi:10.1001/jamaneurol.2016.5042

This study reports on the effect of depression on the risk of epilepsy and seizure outcomes.

Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer SymptomsModeling Using an Autopsy Cohort and Application to Clinical Trial Design

Abstract Full Text
JAMA Neurol. 2017;74(5):540-548. doi:10.1001/jamaneurol.2016.5953

This study evaluates neurofibrillary tangle burden in the presence of moderate or frequent plaques and its ability to predict clinical rate of Alzheimer diesase progression.

Two Paradigms for Endovascular Thrombectomy After Intravenous Thrombolysis for Acute Ischemic Stroke

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(5):549-556. doi:10.1001/jamaneurol.2016.5823

This study compares the functional independence at 3 months between patients treated for acute ischemic stroke under the drip-and-ship paradigm and those treated on site (mothership paradigm).

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

Abstract Full Text
open access
JAMA Neurol. 2017;74(5):557-566. doi:10.1001/jamaneurol.2016.6117

This case-control study compares patients with mild cognitive impairment, patients with AD dementia, and cognitively healthy patients to test whether plasma neurofilament light concentrations are increased in patients with AD and associated with cognitive decline, other AD biomarkers, and imaging evidence of neurodegeneration.

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)

Abstract Full Text
JAMA Neurol. 2017;74(5):567-573. doi:10.1001/jamaneurol.2016.5778

This study aims to determine if antioxidant supplements (vitamin E or selenium) used alone or in combination can prevent dementia in asymptomatic older men.

Retinal Architecture and Melanopsin-Mediated Pupillary Response CharacteristicsA Putative Pathophysiologic Signature for the Retino-Hypothalamic Tract in Multiple Sclerosis

Abstract Full Text
has multimedia
JAMA Neurol. 2017;74(5):574-582. doi:10.1001/jamaneurol.2016.5131

This case-control study assesses the association of melanopsin-mediated pupillary responses to blue and red light stimuli with abnormalities in retinal architecture in patients with multiple sclerosis.

Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later

Abstract Full Text
JAMA Neurol. 2017;74(5):583-590. doi:10.1001/jamaneurol.2016.6091

This population-based case-control study examines the accumulation of amyloid in adults with childhood-onset epilepsy compared with a group of matched controls.

Clinical Pathologic Conference

Precipitous Deterioration of Motor Function, Cognition, and Behavior

Abstract Full Text
JAMA Neurol. 2017;74(5):591-596. doi:10.1001/jamaneurol.2016.6159

This case report describes a 72-year-old woman who presented with depression, an unexplained dry cough, and a sense of leg weakness and later developed memory and orientation problems, vertigo, and worsening parkinsonism.

Images in Neurology

Human Immunodeficiency Virus Presenting as Progressive Multifocal Leukoencephalopathy Restricted to the Posterior Fossa

Abstract Full Text
JAMA Neurol. 2017;74(5):597-598. doi:10.1001/jamaneurol.2017.0085

A man in his 50s with an unremarkable medical history began experiencing vertigo 1 week after a viral upper respiratory tract infection.

JAMA Neurology Clinical Challenge

Man With Recurrent Paralysis and Cerebral White Matter Lesions

Abstract Full Text
JAMA Neurol. 2017;74(5):599-600. doi:10.1001/jamaneurol.2016.5502

A 21-year-old man had recurrent, transient episodes of dysarthria, dysphagia, and limb weakness over 3 days and later developed weakness and numbness of his limbs, with more severe symptoms on the right side. What is your diagnosis?

The Mystery of the Locking Eye

Abstract Full Text
has multimedia
JAMA Neurol. 2017;74(5):601-602. doi:10.1001/jamaneurol.2016.5710

A 66-year-old woman with a history of a pituitary macroadenoma had intermittent diplopia of several years’ duration, iplopia was frequently present after repeatedly changing direction of gaze, and she noted mild right ptosis. What is your diagnosis?

Action Tremor, Impaired Balance, and Executive Dysfunction in Midlife

Abstract Full Text
JAMA Neurol. 2017;74(5):603-604. doi:10.1001/jamaneurol.2016.4063

A 58-year-old man presented with a 1-year history of severe and progressive action tremor in his dominant hand when writing. What is your diagnosis?

Observation

Aggregation of α-Synuclein in the Gonadal Tissue of 2 Patients With Parkinson Disease

Abstract Full Text
JAMA Neurol. 2017;74(5):606-607. doi:10.1001/jamaneurol.2016.6155

This case series describes 2 patients with Parkinson disease whose gonadal tissue specimens revealed aggregations of α-synuclein.

Comment & Response

Circulating Interleukin 6 in Parkinson Disease

Abstract Full Text
JAMA Neurol. 2017;74(5):607-608. doi:10.1001/jamaneurol.2017.0037

Circulating Interleukin 6 in Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2017;74(5):608. doi:10.1001/jamaneurol.2017.0040

A New Sign of Intracerebral Hematoma Expansion

Abstract Full Text
JAMA Neurol. 2017;74(5):608-609. doi:10.1001/jamaneurol.2017.0070

A New Sign of Intracerebral Hematoma Expansion—Reply

Abstract Full Text
JAMA Neurol. 2017;74(5):609-610. doi:10.1001/jamaneurol.2017.0073

Congenital Zika Virus InfectionBeyond Neonatal Microcephaly

Abstract Full Text
JAMA Neurol. 2017;74(5):610. doi:10.1001/jamaneurol.2017.0048

Congenital Zika Virus InfectionBeyond Neonatal Microcephaly—Reply

Abstract Full Text
JAMA Neurol. 2017;74(5):610-611. doi:10.1001/jamaneurol.2017.0051

Incorrect Data Used in Statistical Analyses

Abstract Full Text
JAMA Neurol. 2017;74(5):611-612. doi:10.1001/jamaneurol.2016.6106
Correction

Errors in Statistical Analyses

Abstract Full Text
free access
JAMA Neurol. 2017;74(5):612. doi:10.1001/jamaneurol.2016.4681
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2017;74(5):499. doi:10.1001/jamaneurol.2016.3995
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