This population-based case-control study examines the accumulation of amyloid in adults with childhood-onset epilepsy compared with a group of matched controls.
This case-control study compares patients with mild cognitive impairment, patients with AD dementia, and cognitively healthy patients to test whether plasma neurofilament light concentrations are increased in patients with AD and associated with cognitive decline, other AD biomarkers, and imaging evidence of neurodegeneration.
A man in his 50s with an unremarkable medical history began experiencing vertigo 1 week after a viral upper respiratory tract infection.
This longitudinal cohort study examines patterns of neurodegeneration patterns in individuals with β-amyloid peptide–negative suspected non-Alzheimer disease pathophysiology compared with their β-amyloid peptide–positive counterparts.
This study aims to determine if antioxidant supplements (vitamin E or selenium) used alone or in combination can prevent dementia in asymptomatic older men.
This study compares the functional independence at 3 months between patients treated for acute ischemic stroke under the drip-and-ship paradigm and those treated on site (mothership paradigm).
A 58-year-old man presented with a 1-year history of severe and progressive action tremor in his dominant hand when writing. What is your diagnosis?
This study identifies variations in the levels of antioxidant capacity and superoxide dismutase activity between adrenoleukodystrophy phenotypes in patients with cerebral adrenoleukodystrophy or adrenomyeloneuropathy, heterozygote female carriers, and healthy controls and correlates antioxidant levels with clinical outcome scores to determine a possible predictive value.
This study evaluates neurofibrillary tangle burden in the presence of moderate or frequent plaques and its ability to predict clinical rate of Alzheimer diesase progression.
A 66-year-old woman with a history of a pituitary macroadenoma had intermittent diplopia of several years’ duration, iplopia was frequently present after repeatedly changing direction of gaze, and she noted mild right ptosis. What is your diagnosis?
This case series describes 2 patients with Parkinson disease whose gonadal tissue specimens revealed aggregations of α-synuclein.
This Viewpoint discusses medically assisted death in patients with brain injuries in whom functional magnetic resonance imaging that relies on blood oxygen levels in particular brain regions have been used to reveal signals that are interpreted as consciousness.
This study assesses the ability of neurofilament light chain to serve as a diagnostic biomarker in amyotrophic lateral sclerosis and the prognostic value of cerebrospinal fluid neurofilament light chain in patients with amyotrophic lateral sclerosis.
This cohort study examines the association between migraine and ischemic stroke due to cervical artery dissection in young patients with ischemic stroke.
This case report describes a 72-year-old woman who presented with depression, an unexplained dry cough, and a sense of leg weakness and later developed memory and orientation problems, vertigo, and worsening parkinsonism.
A 21-year-old man had recurrent, transient episodes of dysarthria, dysphagia, and limb weakness over 3 days and later developed weakness and numbness of his limbs, with more severe symptoms on the right side. What is your diagnosis?