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Year

Day

April 24, 2017
Viewpoint

Challenges to Translation and the Hippocratic Oath by Premature Termination of Spinal Cord Stem Cell–Based Trials

Abstract Full Text
JAMA Neurol. Published online April 24, 2017. doi:10.1001/jamaneurol.2017.0318

This Viewpoint discusses premature termination of spinal cord injury stem cell–based trials and advocates for clear termination guidelines including an orderly exit plan.

Original Investigation

Clinical Aspects of Glucose Transporter Type 1 DeficiencyInformation From a Global Registry

Abstract Full Text
JAMA Neurol. Published online April 24, 2017. doi:10.1001/jamaneurol.2017.0298

This worldwide patient registry study examines the most common features of glucose transporter type 1 deficiency.

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

Abstract Full Text
JAMA Neurol. Published online April 24, 2017. doi:10.1001/jamaneurol.2017.0357

This study characterizes the transcriptomics of peripheral monocytes in patients with amyotrophic lateral sclerosis.

Clinical Pathologic Conference

A Middle-aged Man With Progressive Ophthalmoparesis, Ataxia, and Spastic Paraparesis

Abstract Full Text
JAMA Neurol. Published online April 24, 2017. doi:10.1001/jamaneurol.2017.0055

This case report describes a 50-year-old man who presented with progressive clumsiness and unsteady gait and whose first symptoms began around age 39 years.

Research Letter

Home-Based Trials in Adolescent MigraineA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online April 24, 2017. doi:10.1001/jamaneurol.2017.0285

This randomized clinical trial assessed the feasibility of a home-based trial of melatonin vs placebo for adolescent migraine prevention.

April 17, 2017
Viewpoint

Enhanced Epilepsy Surveillance and Awareness in the Age of Zika

Abstract Full Text
JAMA Neurol. Published online April 17, 2017. doi:10.1001/jamaneurol.2017.0215

This Viewpoint argues for enhanced seizure and epilepsy awareness and surveillance in infants with congenital ZIKV exposure.

Editorial

Decision Making in AdrenoleukodystrophyWhen Is a Good Outcome Really a Good Outcome?

Abstract Full Text
JAMA Neurol. Published online April 17, 2017. doi:10.1001/jamaneurol.2017.0095
Original Investigation

Neurocognitive Trajectory of Boys Who Received a Hematopoietic Stem Cell Transplant at an Early Stage of Childhood Cerebral Adrenoleukodystrophy

Abstract Full Text
JAMA Neurol. Published online April 17, 2017. doi:10.1001/jamaneurol.2017.0013

This cohort study characterizes neurocognitive outcomes of boys with childhood cerebral adrenoleukodystrophy and early-stage cerebral disease who were treated with an allogeneic hematopoietic stem cell transplant and identifies disease- and treatment-related factors associated with long-term functioning.

Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals

Abstract Full Text
JAMA Neurol. Published online April 17, 2017. doi:10.1001/jamaneurol.2017.0244

This cohort study explores whether amyloid protective factors and Alzheimer disease–pattern neurodegeneration protective factors differ in elderly individuals with Alzheimer disease and identifies midlife risk factors associated with amyloid deposition.

April 10, 2017
Editorial

Are More Young People Having Strokes?—A Simple Question With an Uncertain Answer

Abstract Full Text
JAMA Neurol. Published online April 10, 2017. doi:10.1001/jamaneurol.2017.0161
Original Investigation

Clinical Features, Molecular Heterogeneity, and Prognostic Implications in YARS2-Related Mitochondrial Myopathy

Abstract Full Text
JAMA Neurol. Published online April 10, 2017. doi:10.1001/jamaneurol.2016.4357

This case series study examines the myopathy, lactic acidosis, and sideroblastic anemia associated with YARS2-related mitochondrial disease.

Prevalence of Cardiovascular Risk Factors and Strokes in Younger Adults

Abstract Full Text
JAMA Neurol. Published online April 10, 2017. doi:10.1001/jamaneurol.2017.0020

This analysis of data from the National Inpatient Sample examines whether stroke hospitalization rates have continued to increase and identifies the prevalence of associated stroke risk factors among younger adults aged 18 to 54 years.

Monitored Anesthesia Care vs Intubation for Vertebrobasilar Stroke Endovascular Therapy

Abstract Full Text
JAMA Neurol. Published online April 10, 2017. doi:10.1001/jamaneurol.2017.0192

This case-control study compares clinical and angiographic outcomes between monitored anesthesia care and general anesthesia in patients presenting with vertebrobasilar occlusion strokes.

Comment & Response

Managing Patients With Large Ischemic Core—What Is in a Match?

Abstract Full Text
JAMA Neurol. Published online April 10, 2017. doi:10.1001/jamaneurol.2017.0168

What Is in a Match?—Reply

Abstract Full Text
JAMA Neurol. Published online April 10, 2017. doi:10.1001/jamaneurol.2017.0173
April 3, 2017
Editorial

Maternal Obesity and Epilepsy

Abstract Full Text
JAMA Neurol. Published online April 3, 2017. doi:10.1001/jamaneurol.2017.0119
Original Investigation

Sudden Unexpected Death in Epilepsy Among Patients With Benign Childhood Epilepsy With Centrotemporal Spikes

Abstract Full Text
JAMA Neurol. Published online April 3, 2017. doi:10.1001/jamaneurol.2016.6126

This case series examines whether cases of benign epilepsy with centrotemporal spikes are present in the North American SUDEP (Sudden Unexpected Death in Epilepsy) Registry.

Maternal Body Mass Index in Early Pregnancy and Risk of Epilepsy in Offspring

Abstract Full Text
JAMA Neurol. Published online April 3, 2017. doi:10.1001/jamaneurol.2016.6130

This population-based study evaluates the incidence of childhood-onset epilepsy in mothers who were overweight or obese during early pregnancy.

Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. Published online April 3, 2017. doi:10.1001/jamaneurol.2016.6179

This cohort study examines the prognostic significance of C-reactive protein in amyotrophic lateral sclerosis.

Clinical Pathologic Conference

Intractable Epilepsy and Progressive Cognitive Decline in a Young Man

Abstract Full Text
JAMA Neurol. Published online April 3, 2017. doi:10.1001/jamaneurol.2016.3195

This case report describes adolescent-onset intractable epilepsy associated with myoclonus and neurocognitive decline to dementia in a young man.

JAMA Neurology Clinical Challenge

Multiple Spinal Lesions in an Immunocompetent Young Man

Abstract Full Text
JAMA Neurol. Published online April 3, 2017. doi:10.1001/jamaneurol.2017.0114

A 30-year-old man was referred with progressive quadriplegia that started from the right lower limb and gradually spread to the upper limb and contralateral side. Cerebrospinal fluid testing revealed pleocytosis, elevated protein concentration, and a decreased glucose level, and magnetic resonance imaging of the cervical spine revealed multiple intramedullary lesions. What is your diagnosis?

Comment & Response

Leptomeningeal Enhancement for Multiple SclerosisAnother Radiological Biomarker for a Relapse?

Abstract Full Text
JAMA Neurol. Published online April 3, 2017. doi:10.1001/jamaneurol.2017.0123
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