Treatment of metastatic colorectal cancer has evolved greatly over the past several decades. Once considered a universally fatal diagnosis, development of new systemic therapies have improved prognoses for many patients. There is an increasing interest in incorporating primary tumor resection, historically considered only palliative, into treatment algorithms for management of the primary tumor in metastatic disease. However, data examining the benefit of resection remain conflicting, and so the debate continues.
Patel S, Chang GJ. Primary Tumor Resection in Metastatic Colorectal CancerPlease Pass the Salt. JAMA Oncol. 2015;1(9):1213-1214. doi:10.1001/jamaoncol.2015.2757