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Comment & Response
May 2016

Use of Very Small Embryonic-Like Stem Cells to Avoid Legal, Ethical, and Safety Issues Associated With Oncofertility—Reply

Author Affiliations
  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia
  • 2Division of Reproductive Science in Medicine, Northwestern University, Chicago, Illinois
JAMA Oncol. 2016;2(5):689-690. doi:10.1001/jamaoncol.2016.1008

In Reply We appreciate the opportunity to respond to the Letter from Dr Bhartiya, which raises the possibility that “very small embryonic-like stem cells” (VSELs) may provide fertility options to young patients with cancer.1 We are aware of the new potential that may exist in the ovaries or testis based on the presence of these cells, and look forward to ongoing research on the topic. However, research in this area is preliminary and use of these cells has not been proven to prevent ovarian failure and infertility in cancer survivors.

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