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Comment & Response
June 2016

Multiple Causes of Cardiotoxic Effects in Patients With Chronic Myeloid Leukemia—Reply

Author Affiliations
  • 1Department of Pharmacy, Namur Thrombosis and Hemostasis Center, Namur Research Institute for Life Sciences, University of Namur, Namur, Belgium
JAMA Oncol. 2016;2(6):829. doi:10.1001/jamaoncol.2016.1011

In Reply We read with great interest the comments by Yun et al on our meta-analysis assessing the risk of vascular occlusive events (VOEs) with new-generation tyrosine kinase inhibitors (TKIs). We fully agree that, for all TKIs, dose-response and also clinical pharmacokinetics are of major importance for both efficacy and safety.1 The European Union’s Summary of Product Characteristics for ponatinib provides efficacy and safety data on dose-efficacy and dose-toxicity relationships and a similar description is proposed for nilotinib.2,3 However, we disagree with the estimates provided by Yun et al and we judge that their conclusion needs to be tempered.

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