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JAMA Oncology Clinical Evidence Synopsis
November 2016

Fertility and Early Pregnancy Outcomes Following Conservative Treatment for Cervical Intraepithelial Neoplasia and Early Cervical Cancer

Author Affiliations
  • 1Department of Surgery & Cancer, Faculty of Medicine, Imperial College, London, England
  • 2Queen Charlotte’s & Chelsea-Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England
  • 3Division of Obstetrics-Gynaecology, University Hospital of Ioannina, Greece
JAMA Oncol. 2016;2(11):1496-1498. doi:10.1001/jamaoncol.2016.1839
Abstract

Clinical Question  Does local conservative treatment for cervical intraepithelial neoplasia and early invasive cervical cancer adversely affect successful conception and early pregnancy outcomes in the first and second trimester (<24 weeks of gestation)?

Clinical Application  Local cervical treatment does not adversely affect fertility or first trimester miscarriage, although it is associated with a significant increase in the risk of second trimester miscarriages.

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