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JAMA Oncology Clinical Evidence Synopsis
November 2016

Fertility and Early Pregnancy Outcomes Following Conservative Treatment for Cervical Intraepithelial Neoplasia and Early Cervical Cancer

Author Affiliations
  • 1Department of Surgery & Cancer, Faculty of Medicine, Imperial College, London, England
  • 2Queen Charlotte’s & Chelsea-Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England
  • 3Division of Obstetrics-Gynaecology, University Hospital of Ioannina, Greece
JAMA Oncol. 2016;2(11):1496-1498. doi:10.1001/jamaoncol.2016.1839

Clinical Question  Does local conservative treatment for cervical intraepithelial neoplasia and early invasive cervical cancer adversely affect successful conception and early pregnancy outcomes in the first and second trimester (<24 weeks of gestation)?

Clinical Application  Local cervical treatment does not adversely affect fertility or first trimester miscarriage, although it is associated with a significant increase in the risk of second trimester miscarriages.