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January 2017

Atypical Ductal HyperplasiaWhat Is the Current Risk for Developing Breast Cancer?

Author Affiliations
  • 1Division of Surgical Oncology, Department of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina
JAMA Oncol. 2017;3(1):20-21. doi:10.1001/jamaoncol.2016.3136

Since the 1985 report by Dupont and Page,1 women with atypical hyperplasia have been found to have an increased risk for developing breast cancer. Recent reports with long-term follow-up have shown the absolute risk for developing breast cancer to be within the range of 1% to 2% per year.2 Most of these studies were performed in cohorts starting in the 1960s, before the widespread use of screening mammograms and core biopsies. In the modern era, are we overestimating the risk of women with atypical hyperplasia for developing breast cancer?

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