Following the introduction of prostate-specific antigen (PSA) screening in the early 1990s, there has been a 50% decline in prostate cancer–specific mortality and more than a 70% decline in the incidence of metastases at diagnosis.1 Given the recent declines in PSA screening and prostate cancer incidence, we sought to assess the effect of these changes on prostate cancer presentation.
Hu JC, Nguyen P, Mao J, Halpern J, Shoag J, Wright JD, Sedrakyan A. Increase in Prostate Cancer Distant Metastases at Diagnosis in the United States. JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.5465