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Comment & Response
May 4, 2017

Androgen Deprivation Therapy and Subsequent Dementia

Author Affiliations
  • 1Department of Urology, Stanford University Medical Center, Stanford, California
  • 2Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University Medical College, Seoul, Korea
JAMA Oncol. Published online May 4, 2017. doi:10.1001/jamaoncol.2017.0509

To the Editor To date, only a few reports in the literature provide clinical evidence for the role of androgen deprivation therapy (ADT) in the risk of dementia.13 Among these 3 studies, only the study by Nead et al1 reported a positive association between ADT and the risk of dementia. To explain the discrepancy in the hazard ratio (HR), a better understanding of the methodological differences among studies should be obtained.

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