To the Editor To date, only a few reports in the literature provide clinical evidence for the role of androgen deprivation therapy (ADT) in the risk of dementia.1- 3 Among these 3 studies, only the study by Nead et al1 reported a positive association between ADT and the risk of dementia. To explain the discrepancy in the hazard ratio (HR), a better understanding of the methodological differences among studies should be obtained.
Kim JH, Chung BI. Androgen Deprivation Therapy and Subsequent Dementia. JAMA Oncol. Published online May 04, 2017. doi:10.1001/jamaoncol.2017.0509