This Viewpoint advocates avoiding the use of first-line cetuximab- or panitumumab-containing regimens for patients with RAS wild-type colorectal cancer.
This Viewpoint states that imatinib’s safety and effectiveness compare favorably with those of newer drugs used to treat chronic myeloid leukemia and points out that the expiration of imatinib’s patent confers a substantial cost advantage.
This Viewpoint discusses the slow adoption by the radiation oncology community of hypofractionated whole-breast radiation therapy.
This study reporting a secondary objective of the EURTAC trial found that a sensitive assay can be used to assess epidermal growth factor receptor mutations in circulating free DNA in advanced non-small-cell lung cancer and that the L858R mutation in cfDNA may be a novel surrogate prognostic marker.
The 21-gene recurrence score assay was adopted quickly in clinical practice after Medicare coverage approval in 2006 and utilization seems equitable and consistent with guidelines across geographic and racial groups.
The authors estimate the impact of prior knowledge of MGUS (monoclonal gammopathy of undetermined significance) diagnosis and comorbidities on multiple myeloma (MM) survival. Patients with MM with prior knowledge of MGUS had better MM survival. The observation that a low M-protein concentration at MGUS diagnosis was associated with poorer MM survival may reflect less frequent clinical follow-up. Their observations stress the importance of clinical follow-up in MGUS, regardless of risk stratification.
This randomized clinical trial found that patients perceived a higher level of compassion and preferred physicians who provided a more optimistic message.
There is an association by hospital referral region between inappropriate prostate and breast cancer imaging rates.
This probabilistic decision model study found that the value of providing access to new treatments on the basis of surrogate end points, and progression-free survival in non–small-cell lung cancer in particular, likely varies considerably.
A multicenter cross-sectional cohort study was conducted of individuals recruited to the Colon Cancer Family Registry from 1998 through 2007. In this large cohort of patients with early-onset colorectal cancer, germline TP53 mutations were detected at a frequency comparable with the published prevalence of germline APC mutations in colorectal cancer.
In a survey study to examine racial/ethnic differences in how women selected surgeons/hospitals for breast cancer surgery, the authors found that minority patients were less actively involved in these selections, relying more on physician referral and health plans.
This study found an inverse association between midlife cardiorespiratory fitness (CRF) and incident lung and colorectal cancer but not prostate cancer. High midlife CRF is associated with lower risk of cause-specific mortality in those diagnosed as having cancer at Medicare age.
This gene-sequencing case report found that selective erlotinib use in head and neck squamous cell carcinoma may be informed by precision oncology approaches.
This case series describes outcomes for patients given low-dose decitabine for treatment of isolated thrombocytopenia following allogeneic hematopoietic stem cell transplantation.