This Viewpoint presents 5 strategies to lessen the financial burden of cancer treatment.
This Viewpoint describes how consideration of the cellular and genomic context in which somatic mutations occur will be required for the optimal targeting of cancer treatments.
Concerns have arisen that technical advances in genomics have outpaced our ability to provide safe, ethical care. When guided by appropriate expertise and in conjunction with clinical research, however, multigene panels offer substantial opportunities to improve cancer risk assessment, early detection, and prevention.
A family experience with cancer brings the author to a deeper understanding of the importance of trust in the physician-patient relationship.
The author illustrates through personal narrative how patient trust is necessary for successful patient-physician discussions of treatment options in cases of serious illness.
Children in remission from acute lymphoblastic leukemia and undergoing maintenance therapy with 6-mercaptopurine are at greater risk of relapse if their drug intake is not regularized and closely monitored.
This study examined the influences of hormone therapy on breast cancer incidence during early and late postintervention phases in the Women’s Health Initiative trials, finding greater adverse influence for estrogen + progestin use and somewhat greater benefit for use of estrogen alone.
This retrospective study found that oophorectomy is associated with a decrease in mortality in women with breast cancer and a BRCA1 mutation.
In a retrospective study to determine whether the use of 5α-reductase inhibitors before prostate cancer diagnosis is associated with an increased risk of cancer-specific and all-cause mortality, the authors found no association.
This cross-sectional study finds that axillary evaluation is often conducted in women treated for ductal carcinoma in situ despite guidelines against its use with breast-conserving surgery and uncertainty of benefit with mastectomy.
Men with low-risk and favorable intermediate-risk prostate cancer have similarly low mortality during the first decade after standard brachytherapy, thus supporting initial management of active surveillance for both groups.
This prospective study found that obesity is more strongly associated with increased prostate cancer risk among African American than non-Hispanic white men and thus reducing obesity among African American men could reduce the racial disparity in cancer incidence.
This explorative study finds that ingestion of fish oils and fishes containing relevant levels of 16:4(n-3) should be avoided on days surrounding chemotherapy to avoid potent chemotherapy-negating effects found in preclinical mouse models.
In this study of tumor characteristics and melanoma-specific survival, NRAS+ and BRAF+ melanomas were found to be associated with higher tumor stage at diagnosis, indicating that these melanomas are less likely than wildtype melanoma to be diagnosed when lower risk and surgically curable.
This survey study found that in a placebo-controlled, double-blind randomized clinical trial of breast cancer chemotherapy, unblinding to randomization allocation did not significantly affect most participants’ views except for chance of a serious problem from experimental treatment.
This Special Communication provides perspectives regarding the rationale, barriers, and strategies for integrating patient-reported outcome end points and guidance principles into cancer drug development and US labeling.
This review discusses the development of targeted and immune therapies for advanced melanoma, reviews current patient management, and highlights future directions.