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Year

Day

December 29, 2016
Viewpoint

The High Cost of New Cancer Therapies—A Challenge of Inequality for All Countries

Abstract Full Text
JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.6335

This Viewpoint describes the high cost of new cancer therapies, making comparisons to the early years of the AIDS epidemic, when many patients in low-resource countries died because of the initial high cost of HIV medications.

Cancer Care Chronicles

Processing Death

Abstract Full Text
JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.5105
Brief Report

Association Between Loss-of-Function Mutations Within the FANCM Gene and Early-Onset Familial Breast Cancer

Abstract Full Text
JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.5592

This case-control study analyzed the entire coding region of the FANCM gene to find its association with breast and ovarian cancer risk.

Special Communication

A Standard Set of Value-Based Patient-Centered Outcomes for Breast CancerThe International Consortium for Health Outcomes Measurement (ICHOM) Initiative

Abstract Full Text
JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.4851

This Special Communication examines the development of a standard set of value-based patient-centered outcomes for breast cancer.

Review

Making Molecular Imaging a Clinical Tool for Precision OncologyA Review

Abstract Full Text
JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.5084

This review discusses the advantages and disadvantages of molecular imaging for use in oncologic clinical trials as well as clinical practice settings.

Research Letter

Increase in Prostate Cancer Distant Metastases at Diagnosis in the United States

Abstract Full Text
JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.5465

This population-based study assesses the effect of the decline in prostate-specific antigen screening and incidence on prostate cancer presentation.

Editor's Note

Determining Penetration of Prostate-Specific Antigen Screening Recommendations

Abstract Full Text
free access
JAMA Oncol. Published online December 29, 2016. doi:10.1001/jamaoncol.2016.5978
December 22, 2016
Viewpoint

Surgery for Patients With Rectal Cancer—Time to Listen to the Patients and Recognize Reality

Abstract Full Text
JAMA Oncol. Published online December 22, 2016. doi:10.1001/jamaoncol.2016.5380

This Viewpoint argues that surgery is not necessary for all patients with rectal cancer who respond to chemoradiation.

Evidence in Favor of Standard Surgical Treatment for Rectal Cancer

Abstract Full Text
JAMA Oncol. Published online December 22, 2016. doi:10.1001/jamaoncol.2016.5397

This Viewpoint argues that that it is premature to practice selective withdrawal of surgery based on the curative contribution of surgery, the lack of reliable predictive biomarkers, and the scarcity of solid evidence in support of this practice.

Brief Report

Association Between Benign Breast Disease in African American and White American Women and Subsequent Triple-Negative Breast Cancer

Abstract Full Text
JAMA Oncol. Published online December 22, 2016. doi:10.1001/jamaoncol.2016.5598

This study examined whether African American women are more susceptable to triple-negative breast cancer.

Comment & Response

The Optimal Body Mass Index Range for Patients With Colorectal Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online December 22, 2016. doi:10.1001/jamaoncol.2016.5280

The Optimal Body Mass Index Range for Patients With Colorectal Cancer

Abstract Full Text
JAMA Oncol. Published online December 22, 2016. doi:10.1001/jamaoncol.2016.5303
December 15, 2016
Original Investigation

Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal AdenomasA Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online December 15, 2016. doi:10.1001/jamaoncol.2016.5917

This randomized clinical trial investigates whether common variants in vitamin D and calcium pathway genes modify the effects of vitamin D3 or calcium supplementation on colorectal adenoma recurrence.

Review

Comparison of Concurrent Use of Thoracic Radiation With Either Carboplatin-Paclitaxel or Cisplatin-Etoposide for Patients With Stage III Non–Small-Cell Lung CancerA Systematic Review

Abstract Full Text
JAMA Oncol. Published online December 15, 2016. doi:10.1001/jamaoncol.2016.4280

This systematic review compares outcomes and toxic effects between thoracic radiation with either cisplatin-etoposide or carboplatin-paclitaxel for patients with stage III non–small-cell lung cancer.

Research Letter

Comparison of 2 Commercially Available Next-Generation Sequencing Platforms in Oncology

Abstract Full Text
JAMA Oncol. Published online December 15, 2016. doi:10.1001/jamaoncol.2016.4983

This study compares reports from 2 next-generation sequencing tests to determine the level of concordance between platforms.

December 8, 2016
Research Letter

Odontoma in a 255-Million-Year-Old Mammalian Forebear

Abstract Full Text
JAMA Oncol. Published online December 8, 2016. doi:10.1001/jamaoncol.2016.5417

This study describes cancer in a 255-million-year-old mammalian forebear and comments on the implications for establishing the phylogenetic and physiologic conditions under which such pathologic conditions first arose.

December 7, 2016
Brief Report

Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases

Abstract Full Text
JAMA Oncol. Published online December 7, 2016. doi:10.1001/jamaoncol.2016.5630

This study attempts to determine whether there are intrinsic subtype differences between primary breast cancer tumors and matched brain metastases (BrM) and to uncover BrM-acquired alterations that are clinically actionable.

December 1, 2016
Viewpoint

Outcome Measurement in Value-Based Payments

Abstract Full Text
JAMA Oncol. Published online December 1, 2016. doi:10.1001/jamaoncol.2016.5375

This Viewpoint discusses quality measures for colorectal, breast, prostate, and lung cancer.

Cancer Care Chronicles

Reimagining the Initial Office Visit

Abstract Full Text
JAMA Oncol. Published online December 1, 2016. doi:10.1001/jamaoncol.2016.4988
Original Investigation

Effect of Fluorouracil, Leucovorin, and Oxaliplatin With or Without Onartuzumab in HER2-Negative, MET-Positive Gastroesophageal AdenocarcinomaThe METGastric Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online December 1, 2016. doi:10.1001/jamaoncol.2016.5580

This randomized clinical trial assesses whether the addition of onartuzumab, a MET antibody, to first-line fluorouracil, leucovorin, and oxaliplatin therapy improves efficacy outcomes in HER2-negative, MET-positive gastroesophageal adenocarcinoma.

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