This Viewpoint describes the high cost of new cancer therapies, making comparisons to the early years of the AIDS epidemic, when many patients in low-resource countries died because of the initial high cost of HIV medications.
This analysis of health technology assessment reports examines the overall survival, quality of life, and safety benefits associated with recently licensed cancer medicines.
This study investigates the patterns and correlates of second opinion use and the effect on chemotherapy decisions.
This case-control study analyzed the entire coding region of the FANCM gene to find its association with breast and ovarian cancer risk.
This Special Communication examines the development of a standard set of value-based patient-centered outcomes for breast cancer.
This review discusses the advantages and disadvantages of molecular imaging for use in oncologic clinical trials as well as clinical practice settings.
This population-based study assesses the effect of the decline in prostate-specific antigen screening and incidence on prostate cancer presentation.
This Viewpoint argues that surgery is not necessary for all patients with rectal cancer who respond to chemoradiation.
This Viewpoint argues that that it is premature to practice selective withdrawal of surgery based on the curative contribution of surgery, the lack of reliable predictive biomarkers, and the scarcity of solid evidence in support of this practice.
This secondary analysis of 2 randomized clinical trials examines the association of DNA mismatch repair status and somatic gene mutations in the primary tumor of patients with stage III colon cancer treated with adjuvant chemotherapy.
This secondary analysis of a randomized clinical trial examines whether a germline mutation in a microRNA-binding site in KRAS is a predictive biomarker of cetuximab response and altered immunity following radiotherapy and cisplatin treatment for head and neck squamous cell cancer.
This study examined whether African American women are more susceptable to triple-negative breast cancer.
A woman in her 80s presented with a 2-week history of an enlarging left parietal scalp mass that continued to enlarge. She subsequently developed progressive generalized weakness, slowed speech, and focal right-handed weakness. What is your diagnosis?
This cohort study examines the frequency and spectrum of cancer susceptibility gene mutations among patients with early-onset colorectal cancer.
This phase 2 randomized clinical trial compares selumetinib and MK-2206 vs modified FOLFOX chemotherapy in patients with metastatic pancreatic cancer for whom gemcitabine-based therapy had failed.
This randomized clinical trial investigates whether common variants in vitamin D and calcium pathway genes modify the effects of vitamin D3 or calcium supplementation on colorectal adenoma recurrence.
This systematic review compares outcomes and toxic effects between thoracic radiation with either cisplatin-etoposide or carboplatin-paclitaxel for patients with stage III non–small-cell lung cancer.
A woman in her 70s presented with progressive supraclavicular, facial, and mandibular swelling of 3 months’ duration; a fixed mass throughout the left preauricular space; and a right supraclavicular mass. What is your diagnosis?
This study compares reports from 2 next-generation sequencing tests to determine the level of concordance between platforms.
This cohort study explores the role of human papillomavirus status in patients with head and neck squamous cell cancer, stratified by race/ethnicity, sex, and oropharyngeal squamous cell carcinoma vs nonoropharyngeal head and neck squamous cell carcinoma.
This population-based study of patients with head and neck cancer investigates whether immunologic response to human papillomavirus 16 is associated with patient survival across anatomic sites, independent of smoking and drinking history.
This randomized clinical trial of patients with locoregionally advanced squamous cell carcinoma of the head and neck compared the effect of accelerated-fractionation radiotherapy (RT) plus the anti–epidermal growth factor receptor antibody panitumumab vs standard-fractionation RT plus high-dose cisplatin on progression-free survival.
This study describes cancer in a 255-million-year-old mammalian forebear and comments on the implications for establishing the phylogenetic and physiologic conditions under which such pathologic conditions first arose.
This study attempts to determine whether there are intrinsic subtype differences between primary breast cancer tumors and matched brain metastases (BrM) and to uncover BrM-acquired alterations that are clinically actionable.
Using the methodology and data sources of the Global Burden of Disease study, this systematic analysis estimates mortality, incidence, years lived with disability, years of life lost, and disability-adjusted life-years for 32 cancers in 195 countries and territories from 1990 to 2015.
This Viewpoint discusses quality measures for colorectal, breast, prostate, and lung cancer.
This randomized clinical trial compares the effects of an 8-week rotating treatment schedule with pazopanib and everolimus vs continuous pazopanibon disease progression in patients with metastatic clear cell renal cell cancer.
This randomized clinical trial assesses whether the addition of onartuzumab, a MET antibody, to first-line fluorouracil, leucovorin, and oxaliplatin therapy improves efficacy outcomes in HER2-negative, MET-positive gastroesophageal adenocarcinoma.
This review discusses the controversies and unanswered questions regarding axillary management in patients receiving neoadjuvant chemotherapy for breast cancer.
This study examines the association of malignant mesothelioma with exposure to asbestos among individuals in Eastern China.