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Year

Day

January 19, 2017
Viewpoint

Is There Room for Second-Line Treatment of Pleural Malignant Mesothelioma?

Abstract Full Text
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JAMA Oncol. Published online January 19, 2017. doi:10.1001/jamaoncol.2016.6135

This Viewpoint discusses the uncertain evidence for second-line treatment of pleural malignant mesothelioma.

Original Investigation

Comparison of Prevalence and Types of Mutations in Lung Cancers Among Black and White Populations

Abstract Full Text
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JAMA Oncol. Published online January 19, 2017. doi:10.1001/jamaoncol.2016.6108

This genomic analysis compares the prevalence and types of mutations in a cohort of black and white patients with lung cancer.

Prevalence of Genital Human Papillomavirus Infection and Human Papillomavirus Vaccination Rates Among US Adult MenNational Health and Nutrition Examination Survey (NHANES) 2013-2014

Abstract Full Text
free access
JAMA Oncol. Published online January 19, 2017. doi:10.1001/jamaoncol.2016.6192

This cross-sectional study of the NHANES 2013-2014 estimates the prevalence of genital human papillomavirus (HPV) infection and the HPV vaccination rate in the United States among adult men and examines potential risk factors for HPV infection.

Brief Report

Topical Imiquimod Plus Nab-paclitaxel for Breast Cancer Cutaneous MetastasesA Phase 2 Clinical Trial

Abstract Full Text
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JAMA Oncol. Published online January 19, 2017. doi:10.1001/jamaoncol.2016.6007

This phase 2, single-arm clinical trial examines the safety and objective response rate of topical imiquimod in combination with systemic chemotherapy for treatment of breast cancer cutaneous metastases.

Frequency of Thyroid Carcinoma in Brazilian TP53 p.R337H Carriers With Li Fraumeni Syndrome

Abstract Full Text
free access
JAMA Oncol. Published online January 19, 2017. doi:10.1001/jamaoncol.2016.6389

This cohort study determines the frequency of thyroid carcinoma in Brazilians with Li Fraumeni syndrome who are carriers of a founder TP53 p.R337H mutation.

JAMA Oncology Clinical Challenge

Large Epigastric Cystic Lesion in a Pregnant Woman

Abstract Full Text
free access
JAMA Oncol. Published online January 19, 2017. doi:10.1001/jamaoncol.2016.5846

A pregnant woman in her 20s presented with abdominal pain and a cystic mass that appeared on scanning results to originate from the body of the pancreas. What is your diagnosis?

January 12, 2017
Cancer Care Chronicles

Escalation of Commitment in Treatment Decisions Near the End of Life

Abstract Full Text
JAMA Oncol. Published online January 12, 2017. doi:10.1001/jamaoncol.2016.5490
Original Investigation

Surrogate End Points for All-Cause Mortality in Men With Localized Unfavorable-Risk Prostate Cancer Treated With Radiation Therapy vs Radiation Therapy Plus Androgen Deprivation TherapyA Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online January 12, 2017. doi:10.1001/jamaoncol.2016.5983

This subgroup analysis of a randomized clinical trial of radiation therapy vs radiation therapy plus androgen deprivation therapy for prostate cancer compares the performance of 4 candidate surrogates for all-cause mortality in men with localized unfavorable-risk prostate cancer using the proportion of treatment-effect metric.

Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide EraA Correlative Analysis Based on NRG Oncology RTOG 0525

Abstract Full Text
JAMA Oncol. Published online January 12, 2017. doi:10.1001/jamaoncol.2016.6020

This secondary analysis of a randomized clinical trial assesses whether molecular variables improve prognostic classification of glioblastomas treated with radiation and temozolomide.

Review

Imaging Locally Advanced, Recurrent, and Metastatic Prostate CancerA Review

Abstract Full Text
JAMA Oncol. Published online January 12, 2017. doi:10.1001/jamaoncol.2016.5840

This review examines recent developments in tumor visualization for locally advanced, recurrent, and metastatic prostate cancer.

Comment & Response

The Significance of Invasive Breast Cancer Associated With Ductal Carcinoma In Situ (DCIS) Compared With Cancer Without Associated DCIS

Abstract Full Text
JAMA Oncol. Published online January 12, 2017. doi:10.1001/jamaoncol.2016.5495
JAMA Oncology Patient Page

Cancer-Related Depression

Abstract Full Text
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JAMA Oncol. Published online January 12, 2017. doi:10.1001/jamaoncol.2016.5851
January 5, 2017
Viewpoint

The Diminishing Role of Whole-Brain Radiation Therapy in the Treatment of Brain Metastases

Abstract Full Text
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.5411

This Viewpoint asserts that there is limited benefit for whole-brain radiation therapy in the treatment of brain metastases.

The Changing Role of Whole-Brain RadiotherapyDemise or Time for Selective Usage?

Abstract Full Text
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.5414

This Viewpoint asserts that whole-brain radiation therapy is beneficial for the treatment of brain metastases.

Original Investigation

Association of Delayed Adjuvant Chemotherapy With Survival After Lung Cancer Surgery

Abstract Full Text
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.5829

This study assesses differences in survival according to the time interval between non–small-cell lung cancer resection and the initiation of postoperative chemotherapy to determine the association between adjuvant treatment timing and efficacy.

Brief Report

Comparison of Survival Outcomes Among Human Papillomavirus–Negative cT1-2 N1-2b Patients With Oropharyngeal Squamous Cell Cancer Treated With Upfront Surgery vs Definitive Chemoradiation TherapyAn Observational Study

Abstract Full Text
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.5769

This study compared survival outcomes among patients with newly diagnosed cT1-2 N1-2b human papillomavirus-negative oropharyngeal squamous cell carcinoma when treated with primary surgical resection vs chemoradiation.

Special Communication

Diagnosis and Management of Waldenström MacroglobulinemiaMayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines 2016

Abstract Full Text
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.5763

This Special Communication provides consensus recommendations for a risk-adapted approach to treatment of Waldenström macroglobulinemia.

Editor's Note

Bringing Adjuvant Chemotherapy for Resected Non–Small-Cell Lung Cancer Into Real-world Practice—Better Late Than Never?

Abstract Full Text
free access
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.5798
Correction

Supplement 2 Added

Abstract Full Text
free access
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.6886
Poetry and Oncology

A Silver Lining

Abstract Full Text
JAMA Oncol. Published online January 5, 2017. doi:10.1001/jamaoncol.2016.5993
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