[Skip to Content]
[Skip to Content Landing]
Citations 0
Editorial
Oct 2011

Rats! Hyperglycemia Protects Against Glaucoma!

Arch Ophthalmol. 2011;129(10):1366-1367. doi:10.1001/archophthalmol.2011.308

From the early 1960s, it has been noted that the prevalence of elevated intraocular pressure (IOP) and open-angle glaucoma (OAG) was increased in patients with diabetes mellitus.1 Population-based studies such as the Barbados Eye Study, the Rotterdam Study, and the Blue Mountains Eye Study have shown that IOP was significantly increased in patients with diabetes.24 These cross-sectional studies have also found a positive association between diabetes and OAG, while studies such as the Baltimore Eye Survey and the African Caribbean Eye Survey did not identify a positive association.5,6 Of significance, a meta-analysis of 5 case-control studies and 7 cross-sectional studies published between 1987 and 2001 showed a positive association between diabetes and OAG, using either a random-effects model (odds ratio = 1.50) or a fixed-effects model (odds ratio = 1.27).7 In a large prospective cohort analysis involving 76 318 women enrolled in the Nurses' Health Study, type 2 diabetes was positively associated with OAG (risk ratio = 1.82) after controlling for age, race, hypertension, body mass index, physical activity, alcohol intake, smoking, and family history of glaucoma.8

First Page Preview View Large
First page PDF preview
First page PDF preview
×