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Dec 2011

Human Herpesvirus 8 in Corneal Endotheliitis Resulting in Graft Failure After Penetrating Keratoplasty Refractory to Allograft Rejection Therapy

Author Affiliations

Author Affiliations: Department of Ophthalmology, Osaka University Medical School, Suita (Drs Inoue, Maeda, and Nishida and Mr Takamatsu), Department of Ophthalmology, Sumitomo Hospital, Osaka (Drs Inoue and Kubota), and Department of Ophthalmology, Toho University Sakura Medical Center, Sakura (Dr Hori), Japan.

Arch Ophthalmol. 2011;129(12):1629-1630. doi:10.1001/archophthalmol.2011.346

Although corneal allograft rejection after penetrating keratoplasty responds to corticosteroids, in some edematous grafts, herpes simplex virus, varicella-zoster virus, or cytomegalovirus causes corneal endotheliitis refractory to steroids and leads to graft failure without appropriate antiviral therapy.1 However, other cases with idiopathic corneal endotheliitis refractory to steroids remain to be studied. Human herpesvirus 8 (HHV-8) is associated with neoplastic diseases.2,3 We report graft failure after penetrating keratoplasty, with aqueous humor positive for HHV-8 DNA by real-time polymerase chain reaction.

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