Kowal et al1 provide an interesting perspective regarding the value of routine testing for antibiotic sensitivity for the management of corneal ulcers. This comes when there is debate concerning the need for routine microbiological culture in the primary management of suspected microbial keratitis.2 They found that 11 (34%) of 32 patients failed to respond to the initial empirical therapy; however, 9 of these patients were sensitive to the antibiotics. For these reasons, the authors question the benefit of routine sensitivity testing, particularly when the other 2 patients who did not respond to the initial therapy were infected with organisms that the therapy was never intended to treat.
Morlet N, Dart J. Routine Antibiotic Sensitivity Testing for Corneal Ulcers. Arch Ophthalmol. 1998;116(9):1262-1263. doi: