HIGIER reports the histories of two brothers having bilateral optic neuritis with bluish discoloration of the temporal halves of the disks. An uncle on the mother's side had been affected with the same trouble. The nature and location of the inflammatory process in this family affection are unknown.
Very similar is another sort of optic-nerve affection, namely, the hereditary specific optic neuritis.
Two cases are then reported of optic-nerve atrophy, one in a girl of twelve and the other in her eight-months-old brother. Since no etiological factors could be discovered, this form of disease must be considered an hereditary or a congenital genuine atrophy affecting all the fibres and not being accompanied by inflammatory symptoms.
A look at the past . . .. Arch Ophthalmol. 1999;117(2):293. doi:10.1001/archopht.117.2.293