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Correspondence
March 2001

Intravitreal Injection of Tissue Plasminogen Activator: Four Considerations

Arch Ophthalmol. 2001;119(3):456-457. doi:

Rapid removal of submacular hemorrhage caused by various diseases is essential to restore visual function. Today the use of intravitreally injected tissue plasminogen activator (tPA) and gas is an effective treatment to displace submacular hemorrhage. The study of Hrach and colleagues,1 which evaluates toxic effects of intravitreally injected commercial tPA solution in the cat retina, is a substantial step toward confirming the safety of this procedure.

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