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We appreciated the interest that Moll et al have shown in our work.
They bring an important conclusion from our study to the attention of the
reader, that considering the use of routine neuroimaging to detect intracranial
tumors in patients with retinoblastoma is warranted. Moll et al suggest using
routine neuroimaging only in patients with familial retinoblastoma because
these patients are at highest risk for development of PNET. However, in our
series, 1 of 86 patients with recognized heritable retinoblastoma who was
screened routinely at 5-month intervals developed PNET between routine screenings,
and 2 of the 3 patients in the series who developed PNET were not recognized
as having heritable retinoblastoma and did not undergo routine neuroimaging.
By routinely imaging only patients with recognized familial retinoblastoma,
only one third of patients in our admittedly small series who developed PNET
would be imaged.
Duncan JL, O'Brien JM. Screening for Pineoblastoma in Patients With Retinoblastoma. Arch Ophthalmol. 2002;120(12):1774. doi: