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July 2001

Additional Factors Linking Corneal Melting to Topical Nonsteroidal Anti-inflammatory Drugs

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Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Ophthalmol. 2001;119(7):1085. doi:

Lin et al1 have provided us with a beautifully illustrated and nicely described group of cases as reported in the August 2000 issue of the ARCHIVES. Their case report makes one wonder if other factors might be contributing to the corneal melting in these patients treated with diclofenac sodium.

Specifically, cases 3, 4, and 5 describe perforations occurring in eyes treated with corticosteroids. These bring to mind the 25 cases of corneal melting that Thygeson2 reported in 1977, which he believed were related to steroids and herpetic infection. Could these be important factors in 1 or more of the authors' cases? It might also be helpful to know the working diagnosis for which diclofenac was used in cases 1, 2, 3, and 5.

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