We welcome the thoughtful comments of Dr Flach regarding our article
on corneal melting associated with topical nonsteroidal anti-inflammatory
drugs after ocular surgery. It is always possible that other factors contributed
to the corneal melting in these patients treated with diclofenac sodium.
Topical steroids are routinely used following ocular surgery. None of
our patients had a history of herpes simplex viral keratitis. Although topical
steroids are known to promote corneal melting in patients with epithelial
defects, none of our patients had such defects when treatment with topical
steroids and diclofenac was initiated.
Cohen EJ. Additional Factors Linking Corneal Melting to Topical Nonsteroidal Anti-inflammatory Drugs. Arch Ophthalmol. 2001;119(7):1085. doi: