We thank Dr Jonas for his suggestion to modify the technique of photodynamic
therapy for the treatment of choroidal neovascularization (CNV).
It is important for investigators and ophthalmologists to learn new
treatment strategies. Photodynamic therapy is a novel modality that differs
substantially from previous approaches. Unlike laser photocoagulation, the
laser energy administered in this technique plays a minor role. The energy
levels used do not have any thermal effect, and heat transport due to active
perfusion is irrelevant. The effect of light activation is purely chemical
and is used to induce oxidative mechanisms.1
Currently, 600 mW/cm2 of light are used, approximately 6 times
the dose required to induce photo-oxidation.
Schmidt-Erfurth U. Increasing the Efficiency of Photodynamic Therapy in the Treatment of Subretinal Neovascularization. Arch Ophthalmol. 2001;119(7):1086. doi: